SLC22A13 (solute carrier family 22 member 13)

2009-08-01  

Identity

HGNC
SLC22A13
LOCATION
3p22.2
LOCUSID
9390
ALIAS
OAT10,OCTL1,OCTL3,ORCTL-3,ORCTL3

Other Information

Locus ID:

NCBI: 9390
MIM: 604047
HGNC: 8494
Ensembl: ENSG00000172940

Variants:

dbSNP: 9390
ClinVar: 9390
TCGA: ENSG00000172940
COSMIC: SLC22A13

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172940ENST00000311856Q9Y226
ENSG00000172940ENST00000415844H0Y4Y1
ENSG00000172940ENST00000649621A0A3B3ITC0

Expression (GTEx)

0
1
2
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Nicotinate metabolismREACTOMER-HSA-196807
Nicotinamide salvagingREACTOMER-HSA-197264

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
195360682009The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin.68
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
184112682008Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13).51
241476382014SLC22A13 catalyses unidirectional efflux of aspartate and glutamate at the basolateral membrane of type A intercalated cells in the renal collecting duct.4
192828702009Isolation of ORCTL3 in a novel genetic screen for tumor-specific apoptosis inducers.3
317805262020Dysfunctional missense variant of OAT10/SLC22A13 decreases gout risk and serum uric acid levels.3
250015392014Isolation and characterization of the anticancer gene organic cation transporter like-3 (ORCTL3).2
247698972015The anticancer gene ORCTL3 targets stearoyl-CoA desaturase-1 for tumour-specific apoptosis.1

Citation

Dessen P

SLC22A13 (solute carrier family 22 member 13)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/50999/slc22a13