SLC22A16 (solute carrier family 22 member 16)

2007-02-01  

Identity

HGNC
SLC22A16
LOCATION
6q21
LOCUSID
85413
ALIAS
CT2,FLIPT2,HEL-S-18,OAT6,OCT6,OKB1,dJ261K5.1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 85413
MIM: 608276
HGNC: 20302
Ensembl: ENSG00000004809

Variants:

dbSNP: 85413
ClinVar: 85413
TCGA: ENSG00000004809
COSMIC: SLC22A16

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000004809ENST00000330550Q86VW1
ENSG00000004809ENST00000368919Q86VW1
ENSG00000004809ENST00000368919A0A0K0K1K9
ENSG00000004809ENST00000424139C9JU94
ENSG00000004809ENST00000434949C9JTF8
ENSG00000004809ENST00000437378C9JGT0
ENSG00000004809ENST00000451557X6RE50

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Organic cation/anion/zwitterion transportREACTOMER-HSA-549132
Organic cation transportREACTOMER-HSA-549127

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPD
PA165291922doxorubicinolChemicalClinicalAnnotationassociatedPKPD17559346
PA443560Breast NeoplasmsDiseaseClinicalAnnotationassociatedPKPD17559346, 20179710, 28036387
PA449165cyclophosphamideChemicalClinicalAnnotationassociatedPD20179710, 28036387
PA449412doxorubicinChemicalClinicalAnnotationassociatedPKPD17559346, 20179710, 28036387

References

Pubmed IDYearTitleCitations
201797102010Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide.36
201797102010Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide.36
200371402010The human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5.33
120891492002Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition.27
175593462007Novel SLC22A16 polymorphisms and influence on doxorubicin pharmacokinetics in Asian breast cancer patients.23
175593462007Novel SLC22A16 polymorphisms and influence on doxorubicin pharmacokinetics in Asian breast cancer patients.23
204530002010A Large-scale genetic association study of esophageal adenocarcinoma risk.23
159634652005Characterization of the organic cation transporter SLC22A16: a doxorubicin importer.22
263149882015Whole-exome analysis reveals novel somatic genomic alterations associated with outcome in immunochemotherapy-treated diffuse large B-cell lymphoma.22
123724082002Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters.16

Citation

Dessen P

SLC22A16 (solute carrier family 22 member 16)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46047/slc22a16