SLC22A18 (solute carrier family 22 member 18)

2003-02-01  

Identity

HGNC
SLC22A18
LOCATION
11p15.4
LOCUSID
5002
ALIAS
BWR1A,BWSCR1A,HET,IMPT1,ITM,ORCTL2,SLC22A1L,TSSC5,p45-BWR1A

Other Information

Locus ID:

NCBI: 5002
MIM: 602631
HGNC: 10964
Ensembl: ENSG00000110628

Variants:

dbSNP: 5002
ClinVar: 5002
TCGA: ENSG00000110628
COSMIC: SLC22A18

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110628ENST00000347936Q96BI1
ENSG00000110628ENST00000380574Q96BI1
ENSG00000110628ENST00000449793E9PRM7
ENSG00000110628ENST00000485423E9PMN7
ENSG00000110628ENST00000649076Q96BI1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Organic cation/anion/zwitterion transportREACTOMER-HSA-549132
Organic cation transportREACTOMER-HSA-549127

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
202019242010Genome-wide association study of alcohol dependence implicates a region on chromosome 11.159
254988862015microRNA-137 functions as a tumor suppressor in human non-small cell lung cancer by targeting SLC22A18.18
219368942011Promoter methylation and downregulation of SLC22A18 are associated with the development and progression of human glioma.17
97516281998Somatic mutation of TSSC5, a novel imprinted gene from human chromosome 11p15.5.12
166245172006Gain of imprinting of SLC22A18 sense and antisense transcripts in human breast cancer.12
221537942012Correlation of low SLC22A18 expression with poor prognosis in patients with glioma.10
261965902015Characterization of SLC22A18 as a tumor suppressor and novel biomarker in colorectal cancer.7
163148442006Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105.6
274028792016Parent-of-origin tumourigenesis is mediated by an essential imprinted modifier in SDHD-linked paragangliomas: SLC22A18 and CDKN1C are candidate tumour modifiers.6
211448132011Low expression of SLC22A18 predicts poor survival outcome in patients with breast cancer after surgery.4

Citation

Dessen P

SLC22A18 (solute carrier family 22 member 18)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42316/slc22a18