Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SLC22A18 (solute carrier family 22 member 18)

Identity

Alias_namesORCTL2
BWSCR1A
IMPT1
SLC22A1L
solute carrier family 22 (organic cation transporter), member 1-like
solute carrier family 22, member 18
Alias_symbol (synonym)BWR1A
TSSC5
ITM
Other aliasHET
p45-BWR1A
HGNC (Hugo) SLC22A18
LocusID (NCBI) 5002
Atlas_Id 42316
Location 11p15.4  [Link to chromosome band 11p15]
Location_base_pair Starts at 2899721 and ends at 2925246 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SLC22A18   10964
LRG (Locus Reference Genomic)LRG_1054
Cards
Entrez_Gene (NCBI)SLC22A18  5002  solute carrier family 22 member 18
AliasesBWR1A; BWSCR1A; HET; IMPT1; 
ITM; ORCTL2; SLC22A1L; TSSC5; p45-BWR1A
GeneCards (Weizmann)SLC22A18
Ensembl hg19 (Hinxton)ENSG00000110628 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000110628 [Gene_View]  ENSG00000110628 [Sequence]  chr11:2899721-2925246 [Contig_View]  SLC22A18 [Vega]
ICGC DataPortalENSG00000110628
TCGA cBioPortalSLC22A18
AceView (NCBI)SLC22A18
Genatlas (Paris)SLC22A18
WikiGenes5002
SOURCE (Princeton)SLC22A18
Genetics Home Reference (NIH)SLC22A18
Genomic and cartography
GoldenPath hg38 (UCSC)SLC22A18  -     chr11:2899721-2925246 +  11p15.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLC22A18  -     11p15.4   [Description]    (hg19-Feb_2009)
GoldenPathSLC22A18 - 11p15.4 [CytoView hg19]  SLC22A18 - 11p15.4 [CytoView hg38]
ImmunoBaseENSG00000110628
Mapping of homologs : NCBISLC22A18 [Mapview hg19]  SLC22A18 [Mapview hg38]
OMIM114480   211980   268210   602631   
Gene and transcription
Genbank (Entrez)AB012083 AF028738 AF030302 AF037064 AF059663
RefSeq transcript (Entrez)NM_001315501 NM_001315502 NM_002555 NM_183233
RefSeq genomic (Entrez)NC_000011 NG_011512 NT_187585
Consensus coding sequences : CCDS (NCBI)SLC22A18
Cluster EST : UnigeneHs.50868 [ NCBI ]
CGAP (NCI)Hs.50868
Alternative Splicing GalleryENSG00000110628
Gene ExpressionSLC22A18 [ NCBI-GEO ]   SLC22A18 [ EBI - ARRAY_EXPRESS ]   SLC22A18 [ SEEK ]   SLC22A18 [ MEM ]
Gene Expression Viewer (FireBrowse)SLC22A18 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5002
GTEX Portal (Tissue expression)SLC22A18
Human Protein AtlasENSG00000110628-SLC22A18 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96BI1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96BI1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96BI1
Splice isoforms : SwissVarQ96BI1
PhosPhoSitePlusQ96BI1
Domaine pattern : Prosite (Expaxy)MFS (PS50850)   
Domains : Interpro (EBI)MFS    MFS_dom    MFS_trans_sf    Tet-R_TetA/multi-R_MdtG   
Domain families : Pfam (Sanger)MFS_1 (PF07690)   
Domain families : Pfam (NCBI)pfam07690   
Conserved Domain (NCBI)SLC22A18
DMDM Disease mutations5002
Blocks (Seattle)SLC22A18
SuperfamilyQ96BI1
Human Protein Atlas [tissue]ENSG00000110628-SLC22A18 [tissue]
Peptide AtlasQ96BI1
HPRD04024
IPIIPI00410347   IPI00657733   IPI00981012   
Protein Interaction databases
DIP (DOE-UCLA)Q96BI1
IntAct (EBI)Q96BI1
FunCoupENSG00000110628
BioGRIDSLC22A18
STRING (EMBL)SLC22A18
ZODIACSLC22A18
Ontologies - Pathways
QuickGOQ96BI1
Ontology : AmiGOnuclear envelope  cytoplasm  plasma membrane  excretion  symporter activity  organic cation transport  membrane  integral component of membrane  apical plasma membrane  transmembrane transporter activity  transmembrane transporter activity  ubiquitin protein ligase binding  xenobiotic transport  drug transmembrane export  
Ontology : EGO-EBInuclear envelope  cytoplasm  plasma membrane  excretion  symporter activity  organic cation transport  membrane  integral component of membrane  apical plasma membrane  transmembrane transporter activity  transmembrane transporter activity  ubiquitin protein ligase binding  xenobiotic transport  drug transmembrane export  
NDEx NetworkSLC22A18
Atlas of Cancer Signalling NetworkSLC22A18
Wikipedia pathwaysSLC22A18
Orthology - Evolution
OrthoDB5002
GeneTree (enSembl)ENSG00000110628
Phylogenetic Trees/Animal Genes : TreeFamSLC22A18
HOGENOMQ96BI1
Homologs : HomoloGeneSLC22A18
Homology/Alignments : Family Browser (UCSC)SLC22A18
Gene fusions - Rearrangements
Fusion : QuiverSLC22A18
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLC22A18 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLC22A18
dbVarSLC22A18
ClinVarSLC22A18
1000_GenomesSLC22A18 
Exome Variant ServerSLC22A18
ExAC (Exome Aggregation Consortium)ENSG00000110628
GNOMAD BrowserENSG00000110628
Varsome BrowserSLC22A18
Genetic variants : HAPMAP5002
Genomic Variants (DGV)SLC22A18 [DGVbeta]
DECIPHERSLC22A18 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLC22A18 
Mutations
ICGC Data PortalSLC22A18 
TCGA Data PortalSLC22A18 
Broad Tumor PortalSLC22A18
OASIS PortalSLC22A18 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLC22A18  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSLC22A18
Mutations and Diseases : HGMDSLC22A18
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SLC22A18
DgiDB (Drug Gene Interaction Database)SLC22A18
DoCM (Curated mutations)SLC22A18 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLC22A18 (select a term)
intoGenSLC22A18
Cancer3DSLC22A18(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM114480    211980    268210    602631   
Orphanet19054   
DisGeNETSLC22A18
MedgenSLC22A18
Genetic Testing Registry SLC22A18
NextProtQ96BI1 [Medical]
TSGene5002
GENETestsSLC22A18
Target ValidationSLC22A18
Huge Navigator SLC22A18 [HugePedia]
snp3D : Map Gene to Disease5002
BioCentury BCIQSLC22A18
ClinGenSLC22A18 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5002
Chemical/Pharm GKB GenePA35846
Clinical trialSLC22A18
Miscellaneous
canSAR (ICR)SLC22A18 (select the gene name)
DataMed IndexSLC22A18
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSLC22A18
EVEXSLC22A18
GoPubMedSLC22A18
iHOPSLC22A18
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 18:07:45 CET 2019
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