Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6582
MIM: 602608
HGNC: 10966
Ensembl: ENSG00000112499
Variants:
dbSNP: 6582
ClinVar: 6582
TCGA: ENSG00000112499
COSMIC: SLC22A2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000112499 | ENST00000366952 | Q5T7Q5 |
| ENSG00000112499 | ENST00000366953 | O15244 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10323 | l-tryptophan | Chemical | ClinicalAnnotation | associated | PK | 22590580 | |
| PA130620651 | anthracyclines and related substances | Chemical | ClinicalAnnotation | associated | PD | 21900104, 23441093 | |
| PA162263534 | Ototoxicity | Disease | ClinicalAnnotation | associated | PD | 25823781, 27457817, 28448657 | |
| PA164713176 | Platinum compounds | Chemical | ClinicalAnnotation | associated | PD | ||
| PA166123389 | fampridine | Chemical | LabelAnnotation, Literature, MultilinkAnnotation | associated | 24433361 | ||
| PA166123756 | creatinine clearance | Disease | MultilinkAnnotation | associated | 22223530 | ||
| PA443622 | Carcinoma, Non-Small-Cell Lung | Disease | ClinicalAnnotation | associated | PD | ||
| PA445062 | Neoplasms | Disease | ClinicalAnnotation | associated | PK | PD | 21900104, 21902499, 23441093 |
| PA449014 | cisplatin | Chemical | ClinicalAnnotation, MultilinkAnnotation | associated | PK | PD | 21902499, 22223530, 25823781, 27457817, 28448657 |
| PA450163 | lamivudine | Chemical | Pathway | associated | |||
| PA450395 | metformin | Chemical | ClinicalAnnotation, Literature, MultilinkAnnotation, Pathway | associated | PK | 22722338, 23417334, 24624919, 25939711 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36331012 | 2023 | The SLC22A2 gene is a determinant of hematological toxicity of oxaliplatin in patients with colorectal cancer. | 0 |
| 36331012 | 2023 | The SLC22A2 gene is a determinant of hematological toxicity of oxaliplatin in patients with colorectal cancer. | 0 |
| 34902340 | 2022 | Molecular basis for stereoselective transport of fenoterol by the organic cation transporters 1 and 2. | 6 |
| 35143948 | 2022 | Promoter haplotype structure of solute carrier 22 member 2 (SLC22A2) in the Xhosa population of South Africa and their differential effect on gene expression. | 0 |
| 35163014 | 2022 | Role of Organic Cation Transporter 2 in Autophagy Induced by Platinum Derivatives. | 1 |
| 35163393 | 2022 | Transport Turnover Rates for Human OCT2 and MATE1 Expressed in Chinese Hamster Ovary Cells. | 6 |
| 34902340 | 2022 | Molecular basis for stereoselective transport of fenoterol by the organic cation transporters 1 and 2. | 6 |
| 35143948 | 2022 | Promoter haplotype structure of solute carrier 22 member 2 (SLC22A2) in the Xhosa population of South Africa and their differential effect on gene expression. | 0 |
| 35163014 | 2022 | Role of Organic Cation Transporter 2 in Autophagy Induced by Platinum Derivatives. | 1 |
| 35163393 | 2022 | Transport Turnover Rates for Human OCT2 and MATE1 Expressed in Chinese Hamster Ovary Cells. | 6 |
| 33177341 | 2021 | Rosai-Dorfman Disease Displays a Unique Monocyte-Macrophage Phenotype Characterized by Expression of OCT2. | 16 |
| 33581269 | 2021 | Low HDL concentration in rs2048327-G carriers can predispose men to develop coronary heart disease: Tehran Cardiometabolic genetic study (TCGS). | 3 |
| 33737618 | 2021 | Effects of SLC22A2 808G>T polymorphism and bosutinib concentrations on serum creatinine in patients with chronic myeloid leukemia receiving bosutinib therapy. | 2 |
| 34502566 | 2021 | Properties of Transport Mediated by the Human Organic Cation Transporter 2 Studied in a Polarized Three-Dimensional Epithelial Cell Culture Model. | 6 |
| 34884730 | 2021 | Substrate-Dependent Trans-Stimulation of Organic Cation Transporter 2 Activity. | 2 |
Citation
Dessen P
SLC22A2 (solute carrier family 22 member 2)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46202/slc22a2
