SLC22A6 (solute carrier family 22 member 6)

2007-08-01  

Identity

HGNC
SLC22A6
LOCATION
11q12.3
LOCUSID
9356
ALIAS
HOAT1,OAT1,PAHT,ROAT1

Other Information

Locus ID:

NCBI: 9356
MIM: 607582
HGNC: 10970
Ensembl: ENSG00000197901

Variants:

dbSNP: 9356
ClinVar: 9356
TCGA: ENSG00000197901
COSMIC: SLC22A6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197901ENST00000360421Q4U2R8
ENSG00000197901ENST00000377871Q4U2R8
ENSG00000197901ENST00000421062Q4U2R8
ENSG00000197901ENST00000458333Q4U2R8
ENSG00000197901ENST00000540654F5H0T7

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Organic cation/anion/zwitterion transportREACTOMER-HSA-549132
Organic anion transportREACTOMER-HSA-561048

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10005adefovir dipivoxilChemicalPathway, VariantAnnotationassociatedPK15864112, 15914676
PA10204tenofovirChemicalPathway, VariantAnnotationassociatedPK15914676
PA133950441hmg coa reductase inhibitorsChemicalPathwayassociated
PA134711723aminohippurateChemicalVariantAnnotationnot associated15864112
PA166163418rucaparibChemicalLabelAnnotationassociated
PA448997cidofovirChemicalVariantAnnotationassociatedPK15914676
PA450428methotrexateChemicalPathway, VariantAnnotationambiguous15864112, 21317831, 25502615
PA451089pravastatinChemicalPathwayassociated
PA451954zidovudineChemicalPathwayassociated22960662

References

Pubmed IDYearTitleCitations
194007472009Predictors of kidney tubular dysfunction in HIV-infected patients treated with tenofovir: a pharmacogenetic study.60
188182012008Organic anion transporter OAT1 undergoes constitutive and protein kinase C-regulated trafficking through a dynamin- and clathrin-dependent pathway.55
147493232004Role of glycosylation in the organic anion transporter OAT1.33
159146762005Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6).27
159146762005Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6).27
170383202006A three-dimensional model of human organic anion transporter 1: aromatic amino acids required for substrate transport.24
158641122005Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1).23
128744492003Protein kinase C activation downregulates human organic anion transporter 1-mediated transport through carrier internalization.21
221085722012Interaction and transport of kynurenic acid via human organic anion transporters hOAT1 and hOAT3.19
152842882004Homocysteine and the renal epithelial transport and toxicity of inorganic mercury: role of basolateral transporter organic anion transporter 1.18

Citation

Dessen P

SLC22A6 (solute carrier family 22 member 6)

Atlas Genet Cytogenet Oncol Haematol. 2007-08-01

Online version: http://atlasgeneticsoncology.org/gene/47691/slc22a6