SLC23A1 (solute carrier family 23 member 1)

2007-07-01  

Identity

HGNC
LOCATION
5q31.2
LOCUSID
ALIAS
SLC23A2,SVCT1,YSPL3

Other Information

Locus ID:

NCBI: 9963
MIM: 603790
HGNC: 10974
Ensembl: ENSG00000170482

Variants:

dbSNP: 9963
ClinVar: 9963
TCGA: ENSG00000170482
COSMIC: SLC23A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170482ENST00000348729Q9UHI7
ENSG00000170482ENST00000353963Q9UHI7
ENSG00000170482ENST00000504513H0Y902
ENSG00000170482ENST00000508270H0YAJ1

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Vitamin digestion and absorptionKEGGko04977
Vitamin digestion and absorptionKEGGhsa04977
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Vitamin C (ascorbate) metabolismREACTOMER-HSA-196836

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
159938392005Polarized localization of vitamin C transporters, SVCT1 and SVCT2, in epithelial cells.36
186361242008Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.32
186361242008Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.32
186766802008Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.32
123817352003Up-regulation and polarized expression of the sodium-ascorbic acid transporter SVCT1 in post-confluent differentiated CaCo-2 cells.31
188187482008Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants.31
195275142009Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants.31
190193352009Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants.26
196921682010Genetic susceptibility to distinct bladder cancer subphenotypes.25
163571102006Genetic variation in the sodium-dependent vitamin C transporters, SLC23A1, and SLC23A2 and risk for preterm delivery.24

Citation

Dessen P

SLC23A1 (solute carrier family 23 member 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47612/slc23a1