SLC25A27 (solute carrier family 25 member 27)

2011-10-01 Affiliation

Identity

HGNC

SLC25A27

LOCATION

6p12.3

LOCUSID

9481

ALIAS

UCP4

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9481
MIM: 613725
HGNC: 21065
Ensembl: ENSG00000153291

Variants:

dbSNP: 9481
ClinVar: 9481
TCGA: ENSG00000153291
COSMIC: SLC25A27

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000153291	ENST00000371347	O95847
ENSG00000153291	ENST00000411689	O95847
ENSG00000153291	ENST00000603486	Q5VTS8
ENSG00000153291	ENST00000604127	S4R3J2
ENSG00000153291	ENST00000604217	S4R3J2
ENSG00000153291	ENST00000604616	S4R300

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism	REACTOME	R-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transport	REACTOME	R-HSA-1428517
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	REACTOME	R-HSA-163200
Mitochondrial Uncoupling Proteins	REACTOME	R-HSA-166187
The fatty acid cycling model	REACTOME	R-HSA-167826
The proton buffering model	REACTOME	R-HSA-167827

References

Pubmed ID	Year	Title	Citations
23266187	2013	The mitochondrial transporter family SLC25: identification, properties and physiopathology.	159
16775390	2006	Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress.	61
17035241	2006	Mitochondrial uncoupling protein-4 regulates calcium homeostasis and sensitivity to store depletion-induced apoptosis in neural cells.	41
17601350	2007	A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.	27
19150400	2009	Mitochondrial UCP4 attenuates MPP+ - and dopamine-induced oxidative stress, mitochondrial depolarization, and ATP deficiency in neurons and is interlinked with UCP2 expression.	22
18977241	2008	Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey.	20
22524567	2012	Toward understanding the mechanism of ion transport activity of neuronal uncoupling proteins UCP2, UCP4, and UCP5.	18
20877624	2010	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	17
17066476	2007	Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia.	14
17066476	2007	Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia.	14

Citation

Dessen P

SLC25A27 (solute carrier family 25 member 27)

Atlas Genet Cytogenet Oncol Haematol. 2011-10-01

Online version: http://atlasgeneticsoncology.org/gene/52475/slc25a27