SLC25A31 (solute carrier family 25 member 31)

2014-08-01  

Identity

HGNC
LOCATION
4q28.1
LOCUSID
ALIAS
AAC4,ANT
FUSION GENES

Other Information

Locus ID:

NCBI: 83447
MIM: 610796
HGNC: 25319
Ensembl: ENSG00000151475

Variants:

dbSNP: 83447
ClinVar: 83447
TCGA: ENSG00000151475
COSMIC: SLC25A31

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000151475ENST00000281154Q9H0C2

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Huntington's diseaseKEGGko05016
Calcium signaling pathwayKEGGhsa04020
Parkinson's diseaseKEGGhsa05012
Huntington's diseaseKEGGhsa05016
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA444552HypertensionDiseaseClinicalAnnotationassociatedPD
PA448499atenololChemicalClinicalAnnotationassociatedPD
PA449899hydrochlorothiazideChemicalClinicalAnnotationassociatedPD
PA450480metoprololChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
232661872013The mitochondrial transporter family SLC25: identification, properties and physiopathology.159
171375712007Compartmentalization of a unique ADP/ATP carrier protein SFEC (Sperm Flagellar Energy Carrier, AAC4) with glycolytic enzymes in the fibrous sheath of the human sperm flagellar principal piece.34
195564382009Adenine nucleotide translocase 4 deficiency leads to early meiotic arrest of murine male germ cells.22
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
200609302010The fourth isoform of the adenine nucleotide translocator inhibits mitochondrial apoptosis in cancer cells.8
215329892011Functional expression of human adenine nucleotide translocase 4 in Saccharomyces cerevisiae.6
218278402011Computational analysis of the transcriptional regulation of the adenine nucleotide translocator isoform 4 gene and its role in spermatozoid glycolytic metabolism.4

Citation

Dessen P

SLC25A31 (solute carrier family 25 member 31)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54629/slc25a31