SLC27A4 (solute carrier family 27 member 4)

2014-08-01  

Identity

HGNC
SLC27A4
LOCATION
9q34.11
LOCUSID
10999
ALIAS
ACSVL4,FATP4,IPS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10999
MIM: 604194
HGNC: 10998
Ensembl: ENSG00000167114

Variants:

dbSNP: 10999
ClinVar: 10999
TCGA: ENSG00000167114
COSMIC: SLC27A4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167114ENST00000300456Q6P1M0
ENSG00000167114ENST00000300456A0A024R8D2
ENSG00000167114ENST00000372870Q6P1M0

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
PPAR signaling pathwayKEGGko03320
PPAR signaling pathwayKEGGhsa03320
Fat digestion and absorptionKEGGko04975
Fat digestion and absorptionKEGGhsa04975
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of vitamins, nucleosides, and related moleculesREACTOMER-HSA-425397
Transport of fatty acidsREACTOMER-HSA-804914
Insulin resistanceKEGGhsa04931

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
196313102009Mutations in the fatty acid transport protein 4 gene cause the ichthyosis prematurity syndrome.41
179015422007The fatty acid transport protein (FATP) family: very long chain acyl-CoA synthetases or solute carriers?29
204160772010Identification of type 2 diabetes-associated combination of SNPs using support vector machine.26
220287932011The expression and function of fatty acid transport protein-2 and -4 in the murine placenta.24
151680182004Expression of fatty-acid-handling proteins in human adipose tissue in relation to obesity and insulin resistance.20
241205742014Fatty acid transporters in skin development, function and disease.17
245034772014Protein mediated fatty acid uptake: synergy between CD36/FAT-facilitated transport and acyl-CoA synthetase-driven metabolism.15
270167842016Protein expression of fatty acid transporter 2 is polarized to the trophoblast basal plasma membrane and increased in placentas from overweight/obese women.12
222352932012Enhanced fatty acid oxidation and FATP4 protein expression after endurance exercise training in human skeletal muscle.9
232717512013Requirement of fatty acid transport protein 4 for development, maturation, and function of sebaceous glands in a mouse model of ichthyosis prematurity syndrome.9

Citation

Dessen P

SLC27A4 (solute carrier family 27 member 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54633/slc27a4