SLC29A4 (solute carrier family 29 member 4)

2008-09-01  

Identity

HGNC
LOCATION
7p22.1
LOCUSID
ALIAS
ENT4,PMAT
FUSION GENES

Other Information

Locus ID:

NCBI: 222962
MIM: 609149
HGNC: 23097
Ensembl: ENSG00000164638

Variants:

dbSNP: 222962
ClinVar: 222962
TCGA: ENSG00000164638
COSMIC: SLC29A4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164638ENST00000297195Q7RTT9
ENSG00000164638ENST00000396872Q7RTT9
ENSG00000164638ENST00000406453Q7RTT9
ENSG00000164638ENST00000434816C9IYM7
ENSG00000164638ENST00000444741C9JZA2

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of vitamins, nucleosides, and related moleculesREACTOMER-HSA-425397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membraneREACTOMER-HSA-83936

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA450395metforminChemicalPathwayassociated22722338

References

Pubmed IDYearTitleCitations
154481432004Identification and characterization of a novel monoamine transporter in the human brain.82
208587072010Selective transport of monoamine neurotransmitters by human plasma membrane monoamine transporter and organic cation transporter 3.63
160998392005Interaction of organic cations with a newly identified plasma membrane monoamine transporter.58
168737182006Distribution and functional characterization of equilibrative nucleoside transporter-4, a novel cardiac adenosine transporter activated at acidic pH.46
170188402007Membrane localization and pH-dependent transport of a newly cloned organic cation transporter (PMAT) in kidney cells.24
171218262007Molecular determinants of substrate selectivity of a novel organic cation transporter (PMAT) in the SLC29 family.20
203925012010Contribution of adenosine related genes to the risk of depression with disturbed sleep.20
193571812009Podocyte-specific expression of organic cation transporter PMAT: implication in puromycin aminonucleoside nephrotoxicity.13
185235612008Adenosine transporter ENT4 is a direct target of EWS/WT1 translocation product and is highly expressed in desmoplastic small round cell tumor.10
244714942014Predominant role of plasma membrane monoamine transporters in monoamine transport in 1321N1, a human astrocytoma-derived cell line.7

Citation

Dessen P

SLC29A4 (solute carrier family 29 member 4)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50322/slc29a4