SLC2A11 (solute carrier family 2 member 11)

2012-08-01  

Identity

HGNC
SLC2A11
LOCATION
22q11.23
LOCUSID
66035
ALIAS
GLUT10,GLUT11
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 66035
MIM: 610367
HGNC: 14239
Ensembl: ENSG00000133460

Variants:

dbSNP: 66035
ClinVar: 66035
TCGA: ENSG00000133460
COSMIC: SLC2A11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133460ENST00000255830F8WFA8
ENSG00000133460ENST00000316185Q9BYW1
ENSG00000133460ENST00000345044Q9BYW1
ENSG00000133460ENST00000398356Q9BYW1
ENSG00000133460ENST00000403208B5MCM1
ENSG00000133460ENST00000405340F8WB79
ENSG00000133460ENST00000405847B5MCM7
ENSG00000133460ENST00000418102F8WBK0
ENSG00000133460ENST00000423972F8WCV3
ENSG00000133460ENST00000436643F8WBG9
ENSG00000133460ENST00000611880A0A087X018

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Facilitative Na+-independent glucose transportersREACTOMER-HSA-428790
Class II GLUTsREACTOMER-HSA-428776

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
224529792012Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and GLUT11: implications for glucose transporter-directed therapy.51
177106492007A highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins acts as a critical determinant of their substrate selectivity.35
161549052005Characterization of the human SLC2A11 (GLUT11) gene: alternative promoter usage, function, expression, and subcellular distribution of three isoforms, and lack of mouse orthologue.19
194235402009Common variation in genes related to innate immunity and risk of adult glioma.19
204069642010Risk of meningioma and common variation in genes related to innate immunity.12
121757792002Cloning and characterization of glucose transporter 11, a novel sugar transporter that is alternatively spliced in various tissues.9
204387852010Polymorphisms in innate immunity genes and risk of childhood leukemia.5

Citation

Dessen P

SLC2A11 (solute carrier family 2 member 11)

Atlas Genet Cytogenet Oncol Haematol. 2012-08-01

Online version: http://atlasgeneticsoncology.org/gene/52804/slc2a11