SLC2A3 (solute carrier family 2 member 3)

2003-05-01  

Identity

HGNC
LOCATION
12p13.31
LOCUSID
ALIAS
GLUT3
FUSION GENES

Other Information

Locus ID:

NCBI: 6515
MIM: 138170
HGNC: 11007
Ensembl: ENSG00000059804

Variants:

dbSNP: 6515
ClinVar: 6515
TCGA: ENSG00000059804
COSMIC: SLC2A3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000059804ENST00000075120P11169
ENSG00000059804ENST00000544291F5GYR5
ENSG00000059804ENST00000544936F5GYX0

Expression (GTEx)

0
100
200
300
400
500
600
700
800

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Hexose transportREACTOMER-HSA-189200
Glucose transportREACTOMER-HSA-70153
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Facilitative Na+-independent glucose transportersREACTOMER-HSA-428790
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Vitamin C (ascorbate) metabolismREACTOMER-HSA-196836
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
239950672013Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake.140
261769162015Molecular basis of ligand recognition and transport by glucose transporters.80
226453022012Dynamic change of chromatin conformation in response to hypoxia enhances the expression of GLUT3 (SLC2A3) by cooperative interaction of hypoxia-inducible factor 1 and KDM3A.76
222708672012Expression of GLUT1 and GLUT3 glucose transporters in endometrial and breast cancers.64
222659712012MicroRNA-195-5p suppresses glucose uptake and proliferation of human bladder cancer T24 cells by regulating GLUT3 expression.57
192618942009Regulation of glucose transporter 3 surface expression by the AMP-activated protein kinase mediates tolerance to glutamate excitation in neurons.53
147574342004Facilitative glucose transporter gene expression in human lymphocytes, monocytes, and macrophages: a role for GLUT isoforms 1, 3, and 5 in the immune response and foam cell formation.49
219207902011GLUT2 (SLC2A2) is not the principal glucose transporter in human pancreatic beta cells: implications for understanding genetic association signals at this locus.48
203089902011Genome-wide copy number variation analysis in attention-deficit/hyperactivity disorder: association with neuropeptide Y gene dosage in an extended pedigree.47
196594592009Brain glucose transporters, O-GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer's disease.42

Citation

Dessen P

SLC2A3 (solute carrier family 2 member 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42319/slc2a3