SLC35C1 (solute carrier family 35 member C1)

2008-03-01  

Identity

HGNC
LOCATION
11p11.2
LOCUSID
ALIAS
CDG2C,FUCT1

Other Information

Locus ID:

NCBI: 55343
MIM: 605881
HGNC: 20197
Ensembl: ENSG00000181830

Variants:

dbSNP: 55343
ClinVar: 55343
TCGA: ENSG00000181830
COSMIC: SLC35C1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000181830ENST00000314134Q96A29
ENSG00000181830ENST00000314134B3KQH0
ENSG00000181830ENST00000442528Q96A29
ENSG00000181830ENST00000526817E9PS26
ENSG00000181830ENST00000530471E9PPI4

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinREACTOMER-HSA-446193
Synthesis of substrates in N-glycan biosythesisREACTOMER-HSA-446219
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of vitamins, nucleosides, and related moleculesREACTOMER-HSA-425397
Transport of nucleotide sugarsREACTOMER-HSA-727802
GDP-fucose biosynthesisREACTOMER-HSA-6787639

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
382703912023In vivo evidence for GDP-fucose transport in the absence of transporter SLC35C1 and putative transporter SLC35C2.0
382703912023In vivo evidence for GDP-fucose transport in the absence of transporter SLC35C1 and putative transporter SLC35C2.0
343899862021Congenital disorders of glycosylation with defective fucosylation.7
343899862021Congenital disorders of glycosylation with defective fucosylation.7
319619982020Down-regulation of SLC35C1 induces colon cancer through over-activating Wnt pathway.8
319619982020Down-regulation of SLC35C1 induces colon cancer through over-activating Wnt pathway.8
252396882014A novel mutation in leukocyte adhesion deficiency type II/CDGIIc.6
252396882014A novel mutation in leukocyte adhesion deficiency type II/CDGIIc.6
237309292013FX enzyme and GDP-L-Fuc transporter expression in colorectal cancer.9
237309292013FX enzyme and GDP-L-Fuc transporter expression in colorectal cancer.9
221341072012Hematologically important mutations: leukocyte adhesion deficiency (first update).59
224922352012Identification of functional elements of the GDP-fucose transporter SLC35C1 using a novel Chinese hamster ovary mutant.15
221341072012Hematologically important mutations: leukocyte adhesion deficiency (first update).59
224922352012Identification of functional elements of the GDP-fucose transporter SLC35C1 using a novel Chinese hamster ovary mutant.15
178848432007A high expression of GDP-fucose transporter in hepatocellular carcinoma is a key factor for increases in fucosylation.32

Citation

Dessen P

SLC35C1 (solute carrier family 35 member C1)

Atlas Genet Cytogenet Oncol Haematol. 2008-03-01

Online version: http://atlasgeneticsoncology.org/gene/50039/slc35c1