SLC35C1 (solute carrier family 35 member C1)

2008-03-01  

Identity

HGNC
SLC35C1
LOCATION
11p11.2
LOCUSID
55343
ALIAS
CDG2C,FUCT1

Other Information

Locus ID:

NCBI: 55343
MIM: 605881
HGNC: 20197
Ensembl: ENSG00000181830

Variants:

dbSNP: 55343
ClinVar: 55343
TCGA: ENSG00000181830
COSMIC: SLC35C1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000181830ENST00000314134Q96A29
ENSG00000181830ENST00000314134B3KQH0
ENSG00000181830ENST00000442528Q96A29
ENSG00000181830ENST00000526817E9PS26
ENSG00000181830ENST00000530471E9PPI4

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinREACTOMER-HSA-446193
Synthesis of substrates in N-glycan biosythesisREACTOMER-HSA-446219
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of vitamins, nucleosides, and related moleculesREACTOMER-HSA-425397
Transport of nucleotide sugarsREACTOMER-HSA-727802
GDP-fucose biosynthesisREACTOMER-HSA-6787639

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
221341072012Hematologically important mutations: leukocyte adhesion deficiency (first update).31
178848432007A high expression of GDP-fucose transporter in hepatocellular carcinoma is a key factor for increases in fucosylation.21
124068892003Insights into leukocyte adhesion deficiency type 2 from a novel mutation in the GDP-fucose transporter gene.19
164559552006Leukocyte adhesion deficiency II patients with a dual defect of the GDP-fucose transporter.12
224922352012Identification of functional elements of the GDP-fucose transporter SLC35C1 using a novel Chinese hamster ovary mutant.9
237309292013FX enzyme and GDP-L-Fuc transporter expression in colorectal cancer.4
252396882014A novel mutation in leukocyte adhesion deficiency type II/CDGIIc.1

Citation

Dessen P

SLC35C1 (solute carrier family 35 member C1)

Atlas Genet Cytogenet Oncol Haematol. 2008-03-01

Online version: http://atlasgeneticsoncology.org/gene/50039/slc35c1