SLC38A1 (solute carrier family 38 member 1)

2007-09-01  

Identity

HGNC
SLC38A1
LOCATION
12q13.11
LOCUSID
81539
ALIAS
ATA1,NAT2,SAT1,SNAT1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 81539
MIM: 608490
HGNC: 13447
Ensembl: ENSG00000111371

Variants:

dbSNP: 81539
ClinVar: 81539
TCGA: ENSG00000111371
COSMIC: SLC38A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111371ENST00000398637Q9H2H9
ENSG00000111371ENST00000398637A0A024R124
ENSG00000111371ENST00000439706Q9H2H9
ENSG00000111371ENST00000439706A0A024R124
ENSG00000111371ENST00000546893Q9H2H9
ENSG00000111371ENST00000546893A0A024R124
ENSG00000111371ENST00000549049Q9H2H9
ENSG00000111371ENST00000549049A0A024R124
ENSG00000111371ENST00000550173F8VX12
ENSG00000111371ENST00000552197F8VX04
ENSG00000111371ENST00000612161F8VX04

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
GABAergic synapseKEGGko04727
GABAergic synapseKEGGhsa04727
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter uptake and Metabolism In Glial CellsREACTOMER-HSA-112313
Astrocytic Glutamate-Glutamine Uptake And MetabolismREACTOMER-HSA-210455
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Amino acid transport across the plasma membraneREACTOMER-HSA-352230

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
271292762016Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells.44
234088872013Plasmodium falciparum malaria elicits inflammatory responses that dysregulate placental amino acid transport.29
175494072007Activation of a system A amino acid transporter, ATA1/SLC38A1, in human hepatocellular carcinoma and preneoplastic liver tissues.17
238489952013Activation of SNAT1/SLC38A1 in human breast cancer: correlation with p-Akt overexpression.17
205997472010The contribution of SNAT1 to system A amino acid transporter activity in human placental trophoblast.15
203089912011Integrative genome-wide association analysis of cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders.14
203089912011Integrative genome-wide association analysis of cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders.14
206056012011Overexpression of ATA1/SLC38A1 predicts future recurrence and death in Chinese patients with hilar cholangiocarcinoma.10
212199572011Exacerbated vulnerability to oxidative stress in astrocytic C6 glioma cells with stable overexpression of the glutamine transporter slc38a1.10

Citation

Dessen P

SLC38A1 (solute carrier family 38 member 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-09-01

Online version: http://atlasgeneticsoncology.org/gene/49734/slc38a1