SLC38A1 (solute carrier family 38 member 1)

2007-09-01  

Identity

HGNC
SLC38A1
LOCATION
12q13.11
LOCUSID
81539
ALIAS
ATA1,NAT2,SAT1,SNAT1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 81539
MIM: 608490
HGNC: 13447
Ensembl: ENSG00000111371

Variants:

dbSNP: 81539
ClinVar: 81539
TCGA: ENSG00000111371
COSMIC: SLC38A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111371ENST00000398637Q9H2H9
ENSG00000111371ENST00000398637A0A024R124
ENSG00000111371ENST00000439706Q9H2H9
ENSG00000111371ENST00000439706A0A024R124
ENSG00000111371ENST00000546893Q9H2H9
ENSG00000111371ENST00000546893A0A024R124
ENSG00000111371ENST00000549049Q9H2H9
ENSG00000111371ENST00000549049A0A024R124
ENSG00000111371ENST00000550173F8VX12
ENSG00000111371ENST00000552197F8VX04
ENSG00000111371ENST00000612161F8VX04

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
GABAergic synapseKEGGko04727
GABAergic synapseKEGGhsa04727
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter uptake and Metabolism In Glial CellsREACTOMER-HSA-112313
Astrocytic Glutamate-Glutamine Uptake And MetabolismREACTOMER-HSA-210455
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Amino acid transport across the plasma membraneREACTOMER-HSA-352230

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383826912024CENPA promotes glutamine metabolism and tumor progression by up-regulating SLC38A1 in endometrial cancer.0
386589812024OTUD5 promotes the growth of hepatocellular carcinoma by deubiquitinating and stabilizing SLC38A1.0
383826912024CENPA promotes glutamine metabolism and tumor progression by up-regulating SLC38A1 in endometrial cancer.0
386589812024OTUD5 promotes the growth of hepatocellular carcinoma by deubiquitinating and stabilizing SLC38A1.0
356631982022miRNA-432 and SLC38A1 as Predictors of Hepatocellular Carcinoma Complicated with Alcoholic Steatohepatitis.2
356631982022miRNA-432 and SLC38A1 as Predictors of Hepatocellular Carcinoma Complicated with Alcoholic Steatohepatitis.2
337695592021CircRUNX1 functions as an oncogene in colorectal cancer by regulating circRUNX1/miR-485-5p/SLC38A1 axis.9
337695592021CircRUNX1 functions as an oncogene in colorectal cancer by regulating circRUNX1/miR-485-5p/SLC38A1 axis.9
321643272020Functional Consequences of Low Activity of Transport System A for Neutral Amino Acids in Human Bone Marrow Mesenchymal Stem Cells.4
321643272020Functional Consequences of Low Activity of Transport System A for Neutral Amino Acids in Human Bone Marrow Mesenchymal Stem Cells.4
313449872019High expression of SLC38A1 predicts poor prognosis in patients with de novo acute myeloid leukemia.17
313449872019High expression of SLC38A1 predicts poor prognosis in patients with de novo acute myeloid leukemia.17
282244292017SLC38A1 promotes proliferation and migration of human colorectal cancer cells.14
282244292017SLC38A1 promotes proliferation and migration of human colorectal cancer cells.14
270482592016Actin depolymerization mediated loss of SNTA1 phosphorylation and Rac1 activity has implications on ROS production, cell migration and apoptosis.8

Citation

Dessen P

SLC38A1 (solute carrier family 38 member 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-09-01

Online version: http://atlasgeneticsoncology.org/gene/49734/slc38a1