SLC39A7 (solute carrier family 39 member 7)

2016-10-01 Affiliation

Identity

HGNC

SLC39A7

LOCATION

6p21.32

LOCUSID

7922

ALIAS

D6S115E,D6S2244E,H2-KE4,HKE4,KE4,RING5,ZIP7

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7922
MIM: 601416
HGNC: 4927
Ensembl: ENSG00000112473

Variants:

dbSNP: 7922
ClinVar: 7922
TCGA: ENSG00000112473
COSMIC: SLC39A7

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000112473	ENST00000374675	Q92504
ENSG00000112473	ENST00000374675	A0A024RCX7
ENSG00000112473	ENST00000374677	Q92504
ENSG00000112473	ENST00000374677	A0A024RCX7
ENSG00000112473	ENST00000444757	A2AAT0

Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	REACTOME	R-HSA-425366
Metal ion SLC transporters	REACTOME	R-HSA-425410
Zinc transporters	REACTOME	R-HSA-435354
Zinc influx into cells by the SLC39 gene family	REACTOME	R-HSA-442380

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
22317921	2012	Protein kinase CK2 triggers cytosolic zinc signaling pathways by phosphorylation of zinc channel ZIP7.	75
19246244	2009	Zinc transporters and cancer: a potential role for ZIP7 as a hub for tyrosine kinase activation.	70
15705588	2005	The ZIP7 gene (Slc39a7) encodes a zinc transporter involved in zinc homeostasis of the Golgi apparatus.	67
17975119	2008	Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.	65
18583420	2008	ZIP7-mediated intracellular zinc transport contributes to aberrant growth factor signaling in antihormone-resistant breast cancer Cells.	62
19851445	2009	High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.	51
14525538	2004	Structure-function analysis of HKE4, a member of the new LIV-1 subfamily of zinc transporters.	47
25969539	2015	Characterization of Zinc Influx Transporters (ZIPs) in Pancreatic β Cells: ROLES IN REGULATING CYTOSOLIC ZINC HOMEOSTASIS AND INSULIN SECRETION.	21
19023099	2009	Gene variants associated with ischemic stroke: the cardiovascular health study.	16

Citation

Dessen P

SLC39A7 (solute carrier family 39 member 7)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56175/slc39a7