SLC3A2 (solute carrier family 3 member 2)

2007-02-01  

Identity

HGNC
LOCATION
11q12.3
LOCUSID
ALIAS
4F2,4F2HC,4T2HC,CD98,CD98HC,MDU1,NACAE
FUSION GENES

Other Information

Locus ID:

NCBI: 6520
MIM: 158070
HGNC: 11026
Ensembl: ENSG00000168003

Variants:

dbSNP: 6520
ClinVar: 6520
TCGA: ENSG00000168003
COSMIC: SLC3A2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168003ENST00000338663P08195
ENSG00000168003ENST00000377889P08195
ENSG00000168003ENST00000377890P08195
ENSG00000168003ENST00000377891J3KPF3
ENSG00000168003ENST00000535296F5GZS6
ENSG00000168003ENST00000536981F5GZI0
ENSG00000168003ENST00000538084H0YFS2
ENSG00000168003ENST00000539458F5H0E2
ENSG00000168003ENST00000539507H0YFX4
ENSG00000168003ENST00000539891F5H056
ENSG00000168003ENST00000541372F5GZR9
ENSG00000168003ENST00000541425H0YH36
ENSG00000168003ENST00000544377F5H867

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
mTOR signaling pathwayKEGGko04150
mTOR signaling pathwayKEGGhsa04150
Protein digestion and absorptionKEGGko04974
Protein digestion and absorptionKEGGhsa04974
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Basigin interactionsREACTOMER-HSA-210991
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Amino acid transport across the plasma membraneREACTOMER-HSA-352230
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Tryptophan catabolismREACTOMER-HSA-71240
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismREACTOMER-HSA-6788656
FerroptosisKEGGko04216
FerroptosisKEGGhsa04216

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
156251152005CD98hc (SLC3A2) mediates integrin signaling.84
224996702012CD98 at the crossroads of adaptive immunity and cancer.55
220773142012Correlation of L-type amino acid transporter 1 and CD98 expression with triple negative breast cancer prognosis.48
190187762008l-type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms.43
200913332010Correlation of L-methyl-11C-methionine (MET) uptake with L-type amino acid transporter 1 in human gliomas.42
186605012008Identification and characterization of a diamine exporter in colon epithelial cells.34
154858862004CD98hc (SLC3A2) interaction with beta 1 integrins is required for transformation.32
157137502005CD98 modulates integrin beta1 function in polarized epithelial cells.30
188138312008Inhibition of system L (LAT1/CD98hc) reduces the growth of cultured human breast cancer cells.30

Citation

Dessen P

SLC3A2 (solute carrier family 3 member 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46372/slc3a2