SLC44A1 (solute carrier family 44 member 1)

2009-10-01  

Identity

HGNC
LOCATION
9q31.1
LOCUSID
ALIAS
CD92,CDW92,CHTL1,CONATOC,CTL1
FUSION GENES

Other Information

Locus ID:

NCBI: 23446
MIM: 606105
HGNC: 18798
Ensembl: ENSG00000070214

Variants:

dbSNP: 23446
ClinVar: 23446
TCGA: ENSG00000070214
COSMIC: SLC44A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000070214ENST00000374720Q8WWI5
ENSG00000070214ENST00000374720A0A024R151
ENSG00000070214ENST00000374723Q8WWI5
ENSG00000070214ENST00000374724Q8WWI5
ENSG00000070214ENST00000470972Q8WWI5
ENSG00000070214ENST00000470972A0A024R151

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Choline metabolism in cancerKEGGhsa05231
Choline metabolism in cancerKEGGko05231
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Synthesis of PCREACTOMER-HSA-1483191
Choline catabolismREACTOMER-HSA-6798163

References

Pubmed IDYearTitleCitations
193571332009The solute carrier 44A1 is a mitochondrial protein and mediates choline transport.19
163191252006Impaired trafficking of choline transporter-like protein-1 at plasma membrane and inhibition of choline transport in THP-1 monocyte-derived macrophages.14
166091432006Genomic organization, promoter activity, and expression of the human choline transporter-like protein 1.14
211853442011Functional expression of choline transporter-like protein 1 (CTL1) in human neuroblastoma cells and its link to acetylcholine synthesis.14
204106072010Involvement of choline transporter-like proteins, CTL1 and CTL2, in glucocorticoid-induced acceleration of phosphatidylcholine synthesis via increased choline uptake.12
195196612009Detection of choline transporter-like 1 protein CTL1 in neuroblastoma x glioma cells and in the CNS, and its role in choline uptake.11
224832722012The ubiquitous choline transporter SLC44A1.11
239486652013Functional expression of choline transporter-like protein 1 (CTL1) in small cell lung carcinoma cells: a target molecule for lung cancer therapy.11
156917112005Differential expression and regulation of the high-affinity choline transporter CHT1 and choline acetyltransferase in neurons of superior cervical ganglia.7
266715812015Papillary glioneuronal tumors: histological and molecular characteristics and diagnostic value of SLC44A1-PRKCA fusion.6

Citation

Dessen P

SLC44A1 (solute carrier family 44 member 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-10-01

Online version: http://atlasgeneticsoncology.org/gene/51167/slc44a1