SLC47A2 (solute carrier family 47 member 2)

2017-08-01 Affiliation

Identity

HGNC

SLC47A2

LOCATION

17p11.2

LOCUSID

146802

ALIAS

MATE2,MATE2-B,MATE2-K,MATE2K

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 146802
MIM: 609833
HGNC: 26439
Ensembl: ENSG00000180638

Variants:

dbSNP: 146802
ClinVar: 146802
TCGA: ENSG00000180638
COSMIC: SLC47A2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000180638	ENST00000325411	Q86VL8
ENSG00000180638	ENST00000350657	Q86VL8
ENSG00000180638	ENST00000433844	C9JAE6
ENSG00000180638	ENST00000574239	Q86VL8

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	REACTOME	R-HSA-425366

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA166163418	rucaparib	Chemical	LabelAnnotation	associated
PA443886	Diabetes Mellitus	Disease	ClinicalAnnotation	associated	PK	PD	21956618, 23267855, 23652408, 28834135
PA450395	metformin	Chemical	ClinicalAnnotation, Literature, MultilinkAnnotation, Pathway	associated	PK	PD	21956618, 22722338, 23267855, 23417334, 23652408, 24624919, 25939711, 28834135

References

Pubmed ID	Year	Title	Citations
17509534	2007	Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters.	86
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
23267855	2013	The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin.	42
22558177	2012	Exploring the transcriptome of ciliated cells using in silico dissection of human tissues.	36
19158817	2009	Identification of multidrug and toxin extrusion (MATE1 and MATE2-K) variants with complete loss of transport activity.	14
20067714	2009	Functional characteristics of two human MATE transporters: kinetics of cimetidine transport and profiles of inhibition by various compounds.	12
23630107	2013	Precise comparison of protein localization among OCT, OAT, and MATE in human kidney.	12
20016398	2010	Heterozygous variants of multidrug and toxin extrusions (MATE1 and MATE2-K) have little influence on the disposition of metformin in diabetic patients.	10
20016398	2010	Heterozygous variants of multidrug and toxin extrusions (MATE1 and MATE2-K) have little influence on the disposition of metformin in diabetic patients.	10
20047987	2010	Evaluation of 4',6-diamidino-2-phenylindole as a fluorescent probe substrate for rapid assays of the functionality of human multidrug and toxin extrusion proteins.	9

Citation

Dessen P

SLC47A2 (solute carrier family 47 member 2)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/57011/slc47a2