SLC51A (solute carrier family 51 subunit alpha)

2014-11-01  

Identity

HGNC
SLC51A
LOCATION
3q29
LOCUSID
200931
ALIAS
OSTA,OSTalpha

Other Information

Locus ID:

NCBI: 200931
MIM: 612084
HGNC: 29955
Ensembl: ENSG00000163959

Variants:

dbSNP: 200931
ClinVar: 200931
TCGA: ENSG00000163959
COSMIC: SLC51A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163959ENST00000296327Q86UW1
ENSG00000163959ENST00000415111H7C351
ENSG00000163959ENST00000416660C9J2I5
ENSG00000163959ENST00000428985H7C3V2
ENSG00000163959ENST00000442203F8WBV2

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Bile secretionKEGGko04976
Bile secretionKEGGhsa04976

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
163176842005OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia.90
164239202006Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents.86
162695192006The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes.56
162517212006FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine.48
127194322003Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta.43
173324732007Protein-protein interactions and membrane localization of the human organic solute transporter.18
184693002008Reduced ileal expression of OSTalpha-OSTbeta in non-obese gallstone disease.14
225359582012β-Subunit of the Ostα-Ostβ organic solute transporter is required not only for heterodimerization and trafficking but also for function.9
216910992011Pleiotropic functions of the organic solute transporter Ostα-Ostβ.8
247034252015The organic solute transporters alpha and beta are induced by hypoxia in human hepatocytes.8

Citation

Dessen P

SLC51A (solute carrier family 51 subunit alpha)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73457/slc51a