SLC5A3 (solute carrier family 5 member 3)

2007-02-01  

Identity

HGNC
SLC5A3
LOCATION
21q22.11
LOCUSID
6526
ALIAS
BCW2,SMIT,SMIT1,SMIT2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6526
MIM: 600444
HGNC: 11038
Ensembl: ENSG00000198743

Variants:

dbSNP: 6526
ClinVar: 6526
TCGA: ENSG00000198743
COSMIC: SLC5A3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198743ENST00000381151P53794

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Hexose transportREACTOMER-HSA-189200
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Na+-dependent glucose transportersREACTOMER-HSA-428808
Inositol transportersREACTOMER-HSA-429593
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387

References

Pubmed IDYearTitleCitations
373249532023SLC5A3 is important for cervical cancer cell growth.0
373249532023SLC5A3 is important for cervical cancer cell growth.0
357608032022The sodium/myo-inositol co-transporter SLC5A3 promotes non-small cell lung cancer cell growth.5
357608032022The sodium/myo-inositol co-transporter SLC5A3 promotes non-small cell lung cancer cell growth.5
322354742020Myo-Inositol Transporter SLC5A3 Associates with Degenerative Changes and Inflammation in Sporadic Inclusion Body Myositis.10
322354742020Myo-Inositol Transporter SLC5A3 Associates with Degenerative Changes and Inflammation in Sporadic Inclusion Body Myositis.10
281282272017Sodium-myoinositol cotransporter-1, SMIT1, mediates the production of reactive oxygen species induced by hyperglycemia in the heart.31
287932162017SMIT1 Modifies KCNQ Channel Function and Pharmacology by Physical Interaction with the Pore.15
281282272017Sodium-myoinositol cotransporter-1, SMIT1, mediates the production of reactive oxygen species induced by hyperglycemia in the heart.31
287932162017SMIT1 Modifies KCNQ Channel Function and Pharmacology by Physical Interaction with the Pore.15
272175532016Osmoregulatory inositol transporter SMIT1 modulates electrical activity by adjusting PI(4,5)P2 levels.41
272175532016Osmoregulatory inositol transporter SMIT1 modulates electrical activity by adjusting PI(4,5)P2 levels.41
257565252015Hypotonic activation of the myo-inositol transporter SLC5A3 in HEK293 cells probed by cell volumetry, confocal and super-resolution microscopy.19
257565252015Hypotonic activation of the myo-inositol transporter SLC5A3 in HEK293 cells probed by cell volumetry, confocal and super-resolution microscopy.19
249442042014The transport mechanism of the human sodium/myo-inositol transporter 2 (SMIT2/SGLT6), a member of the LeuT structural family.3

Citation

Dessen P

SLC5A3 (solute carrier family 5 member 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45558/slc5a3