SLC7A11 (solute carrier family 7 member 11)

2008-09-01 Affiliation

Identity

HGNC

SLC7A11

LOCATION

4q28.3

LOCUSID

23657

ALIAS

CCBR1,xCT

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 23657
MIM: 607933
HGNC: 11059
Ensembl: ENSG00000151012

Variants:

dbSNP: 23657
ClinVar: 23657
TCGA: ENSG00000151012
COSMIC: SLC7A11

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000151012	ENST00000280612	Q9UPY5
ENSG00000151012	ENST00000509248	H0Y9F9

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Hemostasis	REACTOME	R-HSA-109582
Cell surface interactions at the vascular wall	REACTOME	R-HSA-202733
Basigin interactions	REACTOME	R-HSA-210991
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptides	REACTOME	R-HSA-425393
Amino acid transport across the plasma membrane	REACTOME	R-HSA-352230
Ferroptosis	KEGG	ko04216
Ferroptosis	KEGG	hsa04216

References

Pubmed ID	Year	Title	Citations
24094812	2013	Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target.	166
16574866	2006	Kaposi's sarcoma-associated herpesvirus fusion-entry receptor: cystine transporter xCT.	76
19017641	2009	Basal levels of eIF2alpha phosphorylation determine cellular antioxidant status by regulating ATF4 and xCT expression.	73
18469825	2008	Small interfering RNA-mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema.	72
21510944	2011	MicroRNA-26b is underexpressed in human breast cancer and induces cell apoptosis by targeting SLC7A11.	61
21555518	2011	The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.	60
18648370	2008	The xc- cystine/glutamate antiporter: a mediator of pancreatic cancer growth with a role in drug resistance.	55
24516043	2014	Reduced expression of miRNA-27a modulates cisplatin resistance in bladder cancer by targeting the cystine/glutamate exchanger SLC7A11.	53
19015640	2009	Disruption of xCT inhibits cancer cell metastasis via the caveolin-1/beta-catenin pathway.	52
20053169	2010	Mechanisms of oxidative glutamate toxicity: the glutamate/cystine antiporter system xc- as a neuroprotective drug target.	51

Citation

Dessen P

SLC7A11 (solute carrier family 7 member 11)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50348/slc7a11