SLC7A2 (solute carrier family 7 member 2)

2016-10-01  

Identity

HGNC
LOCATION
8p22
LOCUSID
ALIAS
ATRC2,CAT2,HCAT2
FUSION GENES

Other Information

Locus ID:

NCBI: 6542
MIM: 601872
HGNC: 11060
Ensembl: ENSG00000003989

Variants:

dbSNP: 6542
ClinVar: 6542
TCGA: ENSG00000003989
COSMIC: SLC7A2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000003989ENST00000004531P52569
ENSG00000003989ENST00000398090P52569
ENSG00000003989ENST00000470360P52569
ENSG00000003989ENST00000494857P52569
ENSG00000003989ENST00000522656P52569
ENSG00000003989ENST00000640220A0A1W2PR06

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Amino acid transport across the plasma membraneREACTOMER-HSA-352230

References

Pubmed IDYearTitleCitations
206000192010Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide Production.41
150649522004Cell signalling-mediating insulin increase of mRNA expression for cationic amino acid transporters-1 and -2 and membrane hyperpolarization in human umbilical vein endothelial cells.16
204300342010Regulation of arginine transport and metabolism by protein kinase Calpha in endothelial cells: stimulation of CAT2 transporters and arginase activity.6
127871292003The importance of cationic amino acid transporter expression in human skin.5
286847632017The prognostic biomarker L-homoarginine is a substrate of the cationic amino acid transporters CAT1, CAT2A and CAT2B.5
116658182001Analysis of the genomic organization of the human cationic amino acid transporters CAT-1, CAT-2 and CAT-4.3
240195172013Identification of cysteine residues in human cationic amino acid transporter hCAT-2A that are targets for inhibition by N-ethylmaleimide.3
227871432012A chimera carrying the functional domain of the orphan protein SLC7A14 in the backbone of SLC7A2 mediates trans-stimulated arginine transport.2
285017042017Genetic variation in SLC7A2 interacts with calcium and magnesium intakes in modulating the risk of colorectal polyps.2
181726652008Characterization of cationic amino acid transporters (hCATs) 1 and 2 in human skin.1

Citation

Dessen P

SLC7A2 (solute carrier family 7 member 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56383/slc7a2