SLC7A6 (solute carrier family 7 member 6)

2012-03-01  

Identity

HGNC
LOCATION
16q22.1
LOCUSID
ALIAS
LAT-2,LAT3,y+LAT-2
FUSION GENES

Other Information

Locus ID:

NCBI: 9057
MIM: 605641
HGNC: 11064
Ensembl: ENSG00000103064

Variants:

dbSNP: 9057
ClinVar: 9057
TCGA: ENSG00000103064
COSMIC: SLC7A6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103064ENST00000219343Q92536
ENSG00000103064ENST00000219343A0A024R719
ENSG00000103064ENST00000379152E7EPZ8
ENSG00000103064ENST00000562727H3BSV7
ENSG00000103064ENST00000563080H3BNF5
ENSG00000103064ENST00000563146H3BPV6
ENSG00000103064ENST00000564708H3BSB6
ENSG00000103064ENST00000566454Q92536
ENSG00000103064ENST00000566454A0A024R719
ENSG00000103064ENST00000566579H3BRZ8
ENSG00000103064ENST00000566834H3BUR2
ENSG00000103064ENST00000567346J3QL60
ENSG00000103064ENST00000568024H3BUA4
ENSG00000103064ENST00000568088H3BPK5
ENSG00000103064ENST00000618043E7EPZ8
ENSG00000103064ENST00000648130H3BNF5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Basigin interactionsREACTOMER-HSA-210991
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Amino acid transport across the plasma membraneREACTOMER-HSA-352230

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
240526242013Targeting amino acid transport in metastatic castration-resistant prostate cancer: effects on cell cycle, cell growth, and tumor development.47
220070002011Androgen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport during prostate cancer progression.41
194436422009Amino acid transporter LAT3 is required for podocyte development and function.13
232216992012The involvement of L-type amino acid transporters in theanine transport.1
241427112013Suppression of amino acid transporter LAT3 expression on proliferation of K562 cells.1
313452302019EGF-activated PI3K/Akt signalling coordinates leucine uptake by regulating LAT3 expression in prostate cancer.1

Citation

Dessen P

SLC7A6 (solute carrier family 7 member 6)

Atlas Genet Cytogenet Oncol Haematol. 2012-03-01

Online version: http://atlasgeneticsoncology.org/gene/52642/slc7a6