SLC8A2 (solute carrier family 8 member A2)

2010-08-01  

Identity

HGNC
LOCATION
19q13.32
LOCUSID
ALIAS
NCX2
FUSION GENES

Other Information

Locus ID:

NCBI: 6543
MIM: 601901
HGNC: 11069
Ensembl: ENSG00000118160

Variants:

dbSNP: 6543
ClinVar: 6543
TCGA: ENSG00000118160
COSMIC: SLC8A2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000118160ENST00000236877Q9UPR5
ENSG00000118160ENST00000542837F5H6L7
ENSG00000118160ENST00000594353M0R211
ENSG00000118160ENST00000597014M0R1Z4

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Olfactory transductionKEGGko04740
Calcium signaling pathwayKEGGhsa04020
Olfactory transductionKEGGhsa04740
Protein digestion and absorptionKEGGko04974
Protein digestion and absorptionKEGGhsa04974
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Platelet calcium homeostasisREACTOMER-HSA-418360
Reduction of cytosolic Ca++ levelsREACTOMER-HSA-418359
Muscle contractionREACTOMER-HSA-397014
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Sodium/Calcium exchangersREACTOMER-HSA-425561
Cardiac conductionREACTOMER-HSA-5576891
Ion homeostasisREACTOMER-HSA-5578775
Apelin signaling pathwayKEGGhsa04371

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
218581952011Sodium-calcium exchange in intracellular calcium handling of human airway smooth muscle.27
213826382011High levels of synaptosomal Na(+)-Ca(2+) exchangers (NCX1, NCX2, NCX3) co-localized with amyloid-beta in human cerebral cortex affected by Alzheimer's disease.13
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
232248842013The role of the mitochondrial NCX in the mechanism of neurodegeneration in Parkinson's disease.10
232248902013New roles of NCX in glial cells: activation of microglia in ischemia and differentiation of oligodendrocytes.10
166793222006Inhibitory interaction of the plasma membrane Na+/Ca2+ exchangers with the 14-3-3 proteins.7
201324882010Molecular genetic and epigenetic analysis of NCX2/SLC8A2 at 19q13.3 in human gliomas.4
290472592017The Candidate Tumor Suppressor Gene SLC8A2 Inhibits Invasion, Angiogenesis and Growth of Glioblastoma.2
295948572017Structure-Dynamic Coupling Through Ca<sup>2+</sup>-Binding Regulatory Domains of Mammalian NCX Isoform/Splice Variants.2

Citation

Dessen P

SLC8A2 (solute carrier family 8 member A2)

Atlas Genet Cytogenet Oncol Haematol. 2010-08-01

Online version: http://atlasgeneticsoncology.org/gene/51575/slc8a2