SLC8B1 (solute carrier family 8 member B1)

2014-11-01  

Identity

HGNC
LOCATION
12q24.13
LOCUSID
ALIAS
NCKX6,NCLX,SLC24A6
FUSION GENES

Other Information

Locus ID:

NCBI: 80024
MIM: 609841
HGNC: 26175
Ensembl: ENSG00000089060

Variants:

dbSNP: 80024
ClinVar: 80024
TCGA: ENSG00000089060
COSMIC: SLC8B1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000089060ENST00000202831Q6J4K2
ENSG00000089060ENST00000546737Q6J4K2
ENSG00000089060ENST00000548186F8VWW9
ENSG00000089060ENST00000549069F8VW44
ENSG00000089060ENST00000549181F8VR99
ENSG00000089060ENST00000549372F8VTU4
ENSG00000089060ENST00000549605F8W134
ENSG00000089060ENST00000550047A0A0B4J252
ENSG00000089060ENST00000550672H0YI75
ENSG00000089060ENST00000552014Q6J4K2
ENSG00000089060ENST00000552613F8W134

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Sodium/Calcium exchangersREACTOMER-HSA-425561

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
150600692004Lithium-calcium exchange is mediated by a distinct potassium-independent sodium-calcium exchanger.39
146252812004Molecular cloning of a sixth member of the K+-dependent Na+/Ca2+ exchanger gene family, NCKX6.33
248982482014NCLX protein, but not LETM1, mediates mitochondrial Ca2+ extrusion, thereby limiting Ca2+-induced NAD(P)H production and modulating matrix redox state.31
282199282017Mitochondria control store-operated Ca2+ entry through Na+ and redox signals.17
276274642016Privileged crosstalk between TRPV1 channels and mitochondrial calcium shuttling machinery controls nociception.4
306581532019Functional properties and mode of regulation of the mitochondrial Na+/Ca2+ exchanger, NCLX.3
305668702018Allosteric Regulation of NCLX by Mitochondrial Membrane Potential Links the Metabolic State and Ca2+ Signaling in Mitochondria.1

Citation

Dessen P

SLC8B1 (solute carrier family 8 member B1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73494/slc8b1