SLC9A1 (solute carrier family 9 member A1)

2007-02-01  

Identity

HGNC
LOCATION
1p36.11
LOCUSID
ALIAS
APNH,LIKNS,NHE-1,NHE1,PPP1R143
FUSION GENES

Other Information

Locus ID:

NCBI: 6548
MIM: 107310
HGNC: 11071
Ensembl: ENSG00000090020

Variants:

dbSNP: 6548
ClinVar: 6548
TCGA: ENSG00000090020
COSMIC: SLC9A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000090020ENST00000263980P19634
ENSG00000090020ENST00000374084B1ALD5
ENSG00000090020ENST00000374086P19634

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Regulation of actin cytoskeletonKEGGko04810
Regulation of actin cytoskeletonKEGGhsa04810
Cardiac muscle contractionKEGGhsa04260
Cardiac muscle contractionKEGGko04260
Salivary secretionKEGGko04970
Salivary secretionKEGGhsa04970
Gastric acid secretionKEGGko04971
Gastric acid secretionKEGGhsa04971
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Bile secretionKEGGko04976
Bile secretionKEGGhsa04976
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Adrenergic signaling in cardiomyocytesKEGGhsa04261
Adrenergic signaling in cardiomyocytesKEGGko04261
Thyroid hormone signaling pathwayKEGGhsa04919
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Sodium/Proton exchangersREACTOMER-HSA-425986
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Hyaluronan metabolismREACTOMER-HSA-2142845
Hyaluronan uptake and degradationREACTOMER-HSA-2160916
Apelin signaling pathwayKEGGhsa04371

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA27745ELF2GenePathwayassociated

References

Pubmed IDYearTitleCitations
205476642010NHE1 promotes invadopodial ECM proteolysis through acidification of the peri-invadopodial space.70
173325062007The NHERF1 PDZ2 domain regulates PKA-RhoA-p38-mediated NHE1 activation and invasion in breast tumor cells.61
150965112004The NHE1 Na+/H+ exchanger recruits ezrin/radixin/moesin proteins to regulate Akt-dependent cell survival.50
211700892011Na(V)1.5 enhances breast cancer cell invasiveness by increasing NHE1-dependent H(+) efflux in caveolae.48
233931972013Regulation of the Na+/H+ Exchanger (NHE1) in Breast Cancer Metastasis.48
239026892013NaV1.5 Na⁺ channels allosterically regulate the NHE-1 exchanger and promote the activity of breast cancer cell invadopodia.46
187760422008Activation of Na+/H+ exchanger 1 is sufficient to generate Ca2+ signals that induce cardiac hypertrophy and heart failure.44
248916032014Talin regulates moesin-NHE-1 recruitment to invadopodia and promotes mammary tumor metastasis.43
179166062007pH dependence of melanoma cell migration: protons extruded by NHE1 dominate protons of the bulk solution.41
179818082007Model structure of the Na+/H+ exchanger 1 (NHE1): functional and clinical implications.39

Citation

Dessen P

SLC9A1 (solute carrier family 9 member A1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45988/slc9a1