Identity
HGNC
LOCATION
1p36.11
LOCUSID
ALIAS
APNH,LIKNS,NHE-1,NHE1,PPP1R143
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6548
MIM: 107310
HGNC: 11071
Ensembl: ENSG00000090020
Variants:
dbSNP: 6548
ClinVar: 6548
TCGA: ENSG00000090020
COSMIC: SLC9A1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000090020 | ENST00000263980 | P19634 |
| ENSG00000090020 | ENST00000374084 | B1ALD5 |
| ENSG00000090020 | ENST00000374086 | P19634 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA27745 | ELF2 | Gene | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38520980 | 2024 | Simultaneous disturbance of NHE1 and LOXL2 decreases tumorigenicity of head and neck squamous cell carcinoma. | 0 |
| 38520980 | 2024 | Simultaneous disturbance of NHE1 and LOXL2 decreases tumorigenicity of head and neck squamous cell carcinoma. | 0 |
| 34933181 | 2022 | The positive feedback loop of NHE1-ERK phosphorylation mediated by BRAF(V600E) mutation contributes to tumorigenesis and development of glioblastoma. | 4 |
| 34979106 | 2022 | Hypoxia enhances motility and EMT through the Na(+)/H(+) exchanger NHE-1 in MDA-MB-231 breast cancer cells. | 6 |
| 35084672 | 2022 | Permissive role of Na(+)/H(+) exchanger isoform 1 in migration and invasion of triple-negative basal-like breast cancer cells. | 2 |
| 35339998 | 2022 | Requirement of Na+/H+ Exchanger NHE1 for Vasopressin-Induced Osteogenic Signaling and Calcification in Human Aortic Smooth Muscle Cells. | 1 |
| 34933181 | 2022 | The positive feedback loop of NHE1-ERK phosphorylation mediated by BRAF(V600E) mutation contributes to tumorigenesis and development of glioblastoma. | 4 |
| 34979106 | 2022 | Hypoxia enhances motility and EMT through the Na(+)/H(+) exchanger NHE-1 in MDA-MB-231 breast cancer cells. | 6 |
| 35084672 | 2022 | Permissive role of Na(+)/H(+) exchanger isoform 1 in migration and invasion of triple-negative basal-like breast cancer cells. | 2 |
| 35339998 | 2022 | Requirement of Na+/H+ Exchanger NHE1 for Vasopressin-Induced Osteogenic Signaling and Calcification in Human Aortic Smooth Muscle Cells. | 1 |
| 32841374 | 2021 | Characterization of intracellular buffering power in human induced pluripotent stem cells and the loss of pluripotency is delayed by acidic stimulation and increase of NHE1 activity. | 1 |
| 33201382 | 2021 | Role of Genetic Mutations of the Na(+)/H(+) Exchanger Isoform 1, in Human Disease and Protein Targeting and Activity. | 8 |
| 33655882 | 2021 | Dynamic Na(+)/H(+) exchanger 1 (NHE1) - calmodulin complexes of varying stoichiometry and structure regulate Ca(2+)-dependent NHE1 activation. | 7 |
| 33804289 | 2021 | Screening of 5- and 6-Substituted Amiloride Libraries Identifies Dual-uPA/NHE1 Active and Single Target-Selective Inhibitors. | 9 |
| 34000263 | 2021 | Type-1 Na(+)/H(+) exchanger is a prognostic factor and associate with immune infiltration in liver hepatocellular carcinoma. | 2 |
Citation
Dessen P
SLC9A1 (solute carrier family 9 member A1)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45988/slc9a1
