SLC9A2 (solute carrier family 9 member A2)

2014-06-01  

Identity

HGNC
LOCATION
2q12.1
LOCUSID
ALIAS
NHE2

Other Information

Locus ID:

NCBI: 6549
MIM: 600530
HGNC: 11072
Ensembl: ENSG00000115616

Variants:

dbSNP: 6549
ClinVar: 6549
TCGA: ENSG00000115616
COSMIC: SLC9A2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115616ENST00000233969Q9UBY0

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Sodium/Proton exchangersREACTOMER-HSA-425986

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA27745ELF2GenePathwayassociated

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
190567652009Functional coupling of the downregulated in adenoma Cl-/base exchanger DRA and the apical Na+/H+ exchangers NHE2 and NHE3.25
193898062009Morphological adaptation with preserved proliferation/transporter content in the colon of patients with short bowel syndrome.14
178814262008Familial pure proximal renal tubular acidosis--a clinical and genetic study.12
179433102008NHE1, NHE2, and NHE4 contribute to regulation of cell pH in T84 colon cancer cells.12
156644172005Gestational profile of Na+/H+ exchanger and Cl-/HCO3- anion exchanger mRNA expression in placenta using real-time QPCR.8
220520142012PKCδ-dependent activation of ERK1/2 leads to upregulation of the human NHE2 transcriptional activity in intestinal epithelial cell line C2BBe1.8
169829552006Extensive genetic analysis of 10 candidate genes for hypertension in Japanese.5
175618092007Sp1 and Sp3 control constitutive expression of the human NHE2 promoter by interactions with the proximal promoter and the transcription initiation site.5
194799402009Interferon-gamma suppresses Na+ -H+ exchanger in cultured human endolymphatic sac epithelial cells.3

Citation

Dessen P

SLC9A2 (solute carrier family 9 member A2)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/53991/slc9a2