SLCO1B1 (solute carrier organic anion transporter family member 1B1)

2010-08-01 Affiliation

Identity

HGNC

SLCO1B1

LOCATION

12p12.1

LOCUSID

10599

ALIAS

HBLRR,LST-1,LST1,OATP-C,OATP1B1,OATP2,OATPC,SLC21A6

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10599
MIM: 604843
HGNC: 10959
Ensembl: ENSG00000134538

Variants:

dbSNP: 10599
ClinVar: 10599
TCGA: ENSG00000134538
COSMIC: SLCO1B1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000134538	ENST00000256958	Q9Y6L6
ENSG00000134538	ENST00000256958	A0A024RAU7

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Bile secretion	KEGG	ko04976
Bile secretion	KEGG	hsa04976
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Transport of vitamins, nucleosides, and related molecules	REACTOME	R-HSA-425397
Transport of organic anions	REACTOME	R-HSA-879518
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Bile acid and bile salt metabolism	REACTOME	R-HSA-194068
Recycling of bile acids and salts	REACTOME	R-HSA-159418

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA10034	bosentan	Chemical	VipGene	associated			17496208
PA10251	atazanavir	Chemical	DataAnnotation	associated
PA128406956	fluorouracil	Chemical	ClinicalAnnotation	associated		PD	27234217
PA133950441	hmg coa reductase inhibitors	Chemical	ClinicalAnnotation, GuidelineAnnotation, Literature, MultilinkAnnotation, Pathway, VipGene	associated	PK	PD	11134001, 11477075, 12670950, 15970799, 16014768, 17177112, 17620857, 18650507, 1092254, 12811365, 15116054, 15226675, 16103896, 16678544, 17015053, 17108811, 17473846, 18650507, 18794729, 21178985, 21243006, 21928084, 22668755, 23361102, 23436703, 23708174, 23930675, 24263182, 24595600, 24598718, 24810685, 25350695, 25446771, 25630984, 25673568, 26086347, 26367500, 28812116
PA134308647	rosuvastatin	Chemical	ClinicalAnnotation, DataAnnotation, LabelAnnotation, Pathway, VariantAnnotation, VipGene	ambiguous	PK	PD	16697742, 17473846, 17568401, 18794729, 22668755, 23930675, 25630984, 28812116
PA142650384	pitavastatin	Chemical	ClinicalAnnotation, LabelAnnotation, VipGene	associated	PK		16595711, 15159445, 20175818, 23007012
PA143414738	atrasentan	Chemical	ClinicalAnnotation, VariantAnnotation, VipGene	associated	PK		16513443
PA164712509	Arsenic compounds	Chemical	VipGene	associated			16479312
PA164742950	olmesartan	Chemical	ClinicalAnnotation, VariantAnnotation, VipGene	associated	PK		18641915
PA164743013	caspofungin	Chemical	VipGene	associated			15716364
PA164748728	mycophenolic acid	Chemical	ClinicalAnnotation	associated	PK		25163792
PA164749431	gemtuzumab ozogamicin	Chemical	ClinicalAnnotation	associated		PD	22584460
PA164754789	conjugated estrogens	Chemical	ClinicalAnnotation, VariantAnnotation	associated			11477075
PA164754992	rocuronium	Chemical	ClinicalAnnotation	associated		PD	25279974
PA165108401	Acute coronary syndrome	Disease	ClinicalAnnotation	associated	PK		25935875
PA165110775	SN-38	Chemical	ClinicalAnnotation	associated		PD	18221820
PA165374673	ticagrelor	Chemical	ClinicalAnnotation	associated	PK		25935875
PA165817016	Kidney Transplantation	Disease	ClinicalAnnotation	associated	PK	PD	21142914, 21878834, 25163792
PA166115842	UGT1A1*28	Haplotype	LabelAnnotation	associated
PA166119041	drug-induced liver injury	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous		PD	22562052
PA166122590	simeprevir	Chemical	LabelAnnotation	associated
PA166129446	simvastatin acid	Chemical	ClinicalAnnotation	associated	PK		25446771, 26367500, 28350522, 29469964
PA166153643	rs1801131	Variant	GuidelineAnnotation	associated
PA166153644	rs1801133	Variant	GuidelineAnnotation	associated
PA166154547	rs2306283	Variant	LabelAnnotation	associated
PA166154575	rs4149032	Variant	LabelAnnotation	associated
PA166154579	rs4149056	Variant	GuidelineAnnotation, LabelAnnotation	associated
PA166154581	rs4149081	Variant	GuidelineAnnotation	associated
PA166154633	rs11045879	Variant	GuidelineAnnotation	associated
PA166155721	rs4148323	Variant	LabelAnnotation	associated
PA166156544	rs2231142	Variant	LabelAnnotation	associated
PA166163391	statin-related myopathy	Disease	ClinicalAnnotation	associated		PD	28812116
PA166163418	rucaparib	Chemical	LabelAnnotation	associated
PA166163438	elbasvir / grazoprevir	Chemical	LabelAnnotation	associated
PA166182348	elagolix	Chemical	LabelAnnotation	associated
PA166183785	amlodipine / atorvastatin / perindopril arginine	Chemical	LabelAnnotation	associated
PA166184379	letermovir	Chemical	ClinicalAnnotation, LabelAnnotation	associated	PK		31022310
PA166184495	ezetimibe / simvastatin	Chemical	LabelAnnotation	associated
PA166184498	ezetimibe / rosuvastatin	Chemical	LabelAnnotation	associated
PA267	ABCB1	Gene	DataAnnotation	associated
PA378	NR1I2	Gene	DataAnnotation	associated
PA390	ABCG2	Gene	DataAnnotation	associated
PA443560	Breast Neoplasms	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	27234217, 30520341
PA443622	Carcinoma, Non-Small-Cell Lung	Disease	ClinicalAnnotation	associated		PD	18221820
PA443796	Coronary Artery Disease	Disease	ClinicalAnnotation	associated		PD	21178985, 21928084, 24595600, 28812116
PA443797	Coronary Disease	Disease	ClinicalAnnotation	associated		PD	22668755
PA443886	Diabetes Mellitus	Disease	ClinicalAnnotation	associated		PD	21178985, 21928084, 24595600, 28812116
PA443890	Diabetes Mellitus, Type 2	Disease	ClinicalAnnotation	associated		PD	27271184
PA443899	Diarrhea	Disease	ClinicalAnnotation	associated		PD	27533851
PA443937	Drug Toxicity	Disease	VariantAnnotation	associated		PD
PA444516	Hypercholesterolemia	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	17473846, 18781850, 18794729, 21178985, 21928084, 22016628, 22668755, 23263738, 23930675, 24595600, 25630984, 26334272, 26932749, 28812116
PA444760	Leukemia, Myeloid, Acute	Disease	ClinicalAnnotation	associated		PD	22584460, 26663398
PA444997	Muscular Diseases	Disease	ClinicalAnnotation	associated	PK	PD	12811365, 15116054, 15226675, 16103896, 16678544, 17015053, 17108811, 17473846, 18650507, 18794729, 21243006, 21928084, 22668755, 23361102, 23708174, 23930675, 24263182, 24595600, 24598718, 25446771, 25630984, 25673568, 26086347, 26367500
PA445062	Neoplasms	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous		PD	18221820, 19390945, 25869015
PA445113	Neutropenia	Disease	VariantAnnotation	not associated		PD	19390945
PA445549	Rhabdomyolysis	Disease	ClinicalAnnotation	associated	PK	PD	12811365, 15116054, 15226675, 16103896, 16678544, 17015053, 17108811, 17473846, 18650507, 18794729, 21243006, 21928084, 22668755, 23361102, 23708174, 23930675, 24263182, 24595600, 24598718, 25446771, 25630984, 25673568, 26086347, 26367500
PA445846	Thrombocytopenia	Disease	ClinicalAnnotation	associated		PD	27533851
PA445941	Tuberculosis	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	21709081
PA446108	Colorectal Neoplasms	Disease	ClinicalAnnotation	associated		PD
PA446155	Precursor Cell Lymphoblastic Leukemia-Lymphoma	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	19901119, 23233662, 23652803, 24712521, 25098908, 28525903, 29683944
PA447048	Myopathy, Central Core	Disease	ClinicalAnnotation	associated	PK	PD	17108811, 18650507, 21243006, 25446771
PA447230	HIV Infections	Disease	ClinicalAnnotation	associated	PK	PD	32022294
PA447288	Essential hypertension	Disease	ClinicalAnnotation	associated		PD
PA448422	amprenavir	Chemical	ClinicalAnnotation	associated	PK
PA448500	atorvastatin	Chemical	ClinicalAnnotation, GuidelineAnnotation, Pathway, VariantAnnotation, VipGene	ambiguous	PK	PD	15616150, 15970779, 10601278, 15970799, 16103896, 17473846, 18794729, 19374892, 19833260, 20040338, 21243006, 21928084, 22016628, 23263738, 23361102, 23876492, 26334272, 26932749
PA448897	cerivastatin	Chemical	ClinicalAnnotation, VariantAnnotation, VipGene	associated		PD	15970799
PA449165	cyclophosphamide	Chemical	ClinicalAnnotation	associated		PD	27234217
PA449177	cytarabine	Chemical	ClinicalAnnotation	associated		PD	22584460, 26663398
PA449212	daunorubicin	Chemical	ClinicalAnnotation	associated		PD	26663398
PA449383	docetaxel	Chemical	ClinicalAnnotation	associated		PD	27234217
PA449412	doxorubicin	Chemical	ClinicalAnnotation	associated		PD	27234217
PA449456	enalapril	Chemical	ClinicalAnnotation, VipGene	associated		PD	16627748
PA449476	epirubicin	Chemical	ClinicalAnnotation	associated		PD	27234217
PA449552	etoposide	Chemical	ClinicalAnnotation	associated		PD	26663398
PA449594	fenofibrate	Chemical	LabelAnnotation	associated
PA449655	fludarabine	Chemical	ClinicalAnnotation	associated		PD	22584460
PA449688	fluvastatin	Chemical	ClinicalAnnotation, GuidelineAnnotation, Pathway, VariantAnnotation	ambiguous		PD	18781850, 18794729
PA449961	idarubicin	Chemical	ClinicalAnnotation	associated		PD	22584460
PA450085	irinotecan	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous		PD	18221820, 19390945, 25869015
PA450112	isoniazid	Chemical	VariantAnnotation	not associated		PD
PA450264	lopinavir	Chemical	ClinicalAnnotation	associated	PK	PD	32022294
PA450272	lovastatin	Chemical	ClinicalAnnotation, Pathway, VariantAnnotation, VipGene	associated	PK	PD	15616150, 10601278, 16103896, 26020121
PA450379	mercaptopurine	Chemical	ClinicalAnnotation	associated		PD	29683944
PA450428	methotrexate	Chemical	ClinicalAnnotation, GuidelineAnnotation, MultilinkAnnotation, Pathway, VariantAnnotation, VipGene	associated	PK	PD	11477075, 19901119, 21317831, 23233662, 23652803, 24712521, 25098908, 25999454, 28525903, 29683944
PA450526	mitoxantrone	Chemical	ClinicalAnnotation	associated		PD	26663398
PA450566	mycophenolate mofetil	Chemical	ClinicalAnnotation	associated	PK	PD	21142914, 21878834
PA450600	nateglinide	Chemical	ClinicalAnnotation, Pathway	associated	PK		18187595
PA450761	paclitaxel	Chemical	VariantAnnotation	associated	PK		30520341
PA451089	pravastatin	Chemical	ClinicalAnnotation, Pathway, VariantAnnotation, VipGene	ambiguous	PK	PD	15970799, 10601278, 12811365, 15116054, 15226675, 15864131, 15970799, 16103896, 16678544, 16722833, 17439540, 17622941, 18794729, 19776292, 19833260, 21851379, 25502615
PA451234	repaglinide	Chemical	ClinicalAnnotation, Pathway, VariantAnnotation, VipGene	ambiguous	PK	PD	18187595, 15961978, 18187595, 18854776, 21327909, 29748863
PA451250	rifampin	Chemical	ClinicalAnnotation	associated	PK	PD	19374892, 21709081, 22562052, 24420746
PA451283	rosiglitazone	Chemical	ClinicalAnnotation, Pathway	associated		PD	27271184
PA451363	simvastatin	Chemical	ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, Pathway, VariantAnnotation, VipGene	ambiguous	PK	PD	11134001, 11477075, 12670950, 15970799, 16014768, 17177112, 17620857, 18650507, 1092254, 17108811, 18650507, 18794729, 21243006, 22617227, 22668755, 23708174, 24598718, 24918167, 25446771
PA451799	troglitazone	Chemical	VipGene	associated			14977862
PA451848	valsartan	Chemical	VipGene	associated			16678545
PA7000	sorafenib	Chemical	ClinicalAnnotation	associated		PD	27533851

References

Pubmed ID	Year	Title	Citations
18650507	2008	SLCO1B1 variants and statin-induced myopathy--a genomewide study.	447
21245207	2011	Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake.	120
19833260	2009	The SLCO1B1*5 genetic variant is associated with statin-induced side effects.	116
19833260	2009	The SLCO1B1*5 genetic variant is associated with statin-induced side effects.	116
17108811	2006	SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid.	103
17108811	2006	SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid.	103
11477075	2001	Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans.	99
19901119	2009	Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.	96
19901119	2009	Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.	96
16198652	2005	Rosuvastatin pharmacokinetics and pharmacogenetics in white and Asian subjects residing in the same environment.	90

Citation

Dessen P

SLCO1B1 (solute carrier organic anion transporter family member 1B1)

Atlas Genet Cytogenet Oncol Haematol. 2010-08-01

Online version: http://atlasgeneticsoncology.org/gene/51592/slco1b1