SLCO1C1 (solute carrier organic anion transporter family member 1C1)

2014-11-01  

Identity

HGNC
SLCO1C1
LOCATION
12p12.2
LOCUSID
53919
ALIAS
OATP-F,OATP1,OATP14,OATP1C1,OATPF,OATPRP5,SLC21A14
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 53919
MIM: 613389
HGNC: 13819
Ensembl: ENSG00000139155

Variants:

dbSNP: 53919
ClinVar: 53919
TCGA: ENSG00000139155
COSMIC: SLCO1C1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139155ENST00000266509Q9NYB5
ENSG00000139155ENST00000539415F5H6S4
ENSG00000139155ENST00000540354Q9NYB5
ENSG00000139155ENST00000545102Q9NYB5
ENSG00000139155ENST00000545604Q9NYB5

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Thyroid hormone signaling pathwayKEGGhsa04919
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of vitamins, nucleosides, and related moleculesREACTOMER-HSA-425397
Transport of organic anionsREACTOMER-HSA-879518

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164713366Tumor necrosis factor alpha (TNF-alpha) inhibitorsChemicalClinicalAnnotationassociatedPD23651021, 25403996, 25493569
PA443434Arthritis, RheumatoidDiseaseClinicalAnnotationassociatedPD23651021, 25403996, 25493569
PA446198Arthritis, PsoriaticDiseaseClinicalAnnotationassociatedPD23651021, 25403996, 25493569
PA449515etanerceptChemicalClinicalAnnotationassociatedPD23651021, 25403996, 25493569
PA452639infliximabChemicalClinicalAnnotationassociatedPD23651021, 25403996, 25493569

References

Pubmed IDYearTitleCitations
186877832008Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier.80
123516932002Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter.64
236510212013GWAS replication study confirms the association of PDE3A-SLCO1C1 with anti-TNF therapy response in rheumatoid arthritis.24
184105472008Polymorphisms in the brain-specific thyroid hormone transporter OATP1C1 are associated with fatigue and depression in hypothyroid patients.20
184105472008Polymorphisms in the brain-specific thyroid hormone transporter OATP1C1 are associated with fatigue and depression in hypothyroid patients.20
192907862009Pharmacogenetics of the organic anion transporting polypeptide 1A2.16
185661132008Thyroid hormone transport and metabolism by organic anion transporter 1C1 and consequences of genetic variation.15
185661132008Thyroid hormone transport and metabolism by organic anion transporter 1C1 and consequences of genetic variation.15
215081342011Expression of thyroid hormone transporters in the human hypothalamus.14
214867662011The expression of thyroid hormone transporters in the human fetal cerebral cortex during early development and in N-Tera-2 neurodifferentiation.11

Citation

Dessen P

SLCO1C1 (solute carrier organic anion transporter family member 1C1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73505/slco1c1