SLCO2A1 (solute carrier organic anion transporter family member 2A1)

2014-08-01  

Identity

HGNC
LOCATION
3q22.1
LOCUSID
ALIAS
MATR1,OATP2A1,PGT,PHOAR2,SLC21A2
FUSION GENES

Other Information

Locus ID:

NCBI: 6578
MIM: 601460
HGNC: 10955
Ensembl: ENSG00000174640

Variants:

dbSNP: 6578
ClinVar: 6578
TCGA: ENSG00000174640
COSMIC: SLCO2A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174640ENST00000310926Q92959
ENSG00000174640ENST00000481359F8W9W8
ENSG00000174640ENST00000493729E7EU40

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of vitamins, nucleosides, and related moleculesREACTOMER-HSA-425397
Transport of organic anionsREACTOMER-HSA-879518

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164713347Thiazides, plainChemicalClinicalAnnotationassociatedPD28783044
PA444534HypernatremiaDiseaseClinicalAnnotationassociatedPD28783044
PA444552HypertensionDiseaseClinicalAnnotationassociatedPD28783044

References

Pubmed IDYearTitleCitations
221974872012Exome sequencing identifies SLCO2A1 mutations as a cause of primary hypertrophic osteoarthropathy.33
191389422008Regulation of prostaglandin transporters in colorectal neoplasia.32
225531282012Prostaglandin transporter mutations cause pachydermoperiostosis with myelofibrosis.22
254331692015Multiple drug resistance-associated protein 4 (MRP4), prostaglandin transporter (PGT), and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) as determinants of PGE2 levels in cancer.20
229064302012Identification of mutations in the prostaglandin transporter gene SLCO2A1 and its phenotype-genotype correlation in Japanese patients with pachydermoperiostosis.19
265397162015A Hereditary Enteropathy Caused by Mutations in the SLCO2A1 Gene, Encoding a Prostaglandin Transporter.19
223316632012Mutations in the prostaglandin transporter encoding gene SLCO2A1 cause primary hypertrophic osteoarthropathy and isolated digital clubbing.15
235091042013Mutations in the SLCO2A1 gene and primary hypertrophic osteoarthropathy: a clinical and biochemical characterization.14
246947552014Genetic variability in key genes in prostaglandin E2 pathway (COX-2, HPGD, ABCC4 and SLCO2A1) and their involvement in colorectal cancer development.14
248389732014Inactivating mutation in the prostaglandin transporter gene, SLCO2A1, associated with familial digital clubbing, colon neoplasia, and NSAID resistance.13

Citation

Dessen P

SLCO2A1 (solute carrier organic anion transporter family member 2A1)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54642/slco2a1