SLCO2B1 (solute carrier organic anion transporter family member 2B1)

2011-07-01  

Identity

HGNC
LOCATION
11q13.4
LOCUSID
ALIAS
OATP-B,OATP2B1,OATPB,SLC21A9
FUSION GENES

Other Information

Locus ID:

NCBI: 11309
MIM: 604988
HGNC: 10962
Ensembl: ENSG00000137491

Variants:

dbSNP: 11309
ClinVar: 11309
TCGA: ENSG00000137491
COSMIC: SLCO2B1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137491ENST00000289575A0A024R5I4
ENSG00000137491ENST00000428359O94956
ENSG00000137491ENST00000454962O94956
ENSG00000137491ENST00000525650A0A0A0MTF1
ENSG00000137491ENST00000525845A0A1B0GX35
ENSG00000137491ENST00000526839H0YE11
ENSG00000137491ENST00000527180E9PI53
ENSG00000137491ENST00000530556A0A1B0GX35
ENSG00000137491ENST00000531713E9PN87
ENSG00000137491ENST00000532236E9PRW4
ENSG00000137491ENST00000534004A0A1B0GX35
ENSG00000137491ENST00000534186E9PIU9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of vitamins, nucleosides, and related moleculesREACTOMER-HSA-425397
Transport of organic anionsREACTOMER-HSA-879518

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA133950441hmg coa reductase inhibitorsChemicalPathwayassociated
PA134308647rosuvastatinChemicalPathwayassociated
PA443450AsthmaDiseaseClinicalAnnotationassociatedPKPD19151602, 23970434
PA448500atorvastatinChemicalPathwayassociated
PA449621fexofenadineChemicalClinicalAnnotationassociatedPK21280267
PA449688fluvastatinChemicalPathwayassociated
PA450272lovastatinChemicalPathwayassociated
PA450546montelukastChemicalClinicalAnnotationassociatedPKPD19151602, 23970434
PA450573nadololChemicalLiterature, MultilinkAnnotationnot associated24419562
PA451089pravastatinChemicalPathwayassociated
PA451363simvastatinChemicalLiterature, MultilinkAnnotation, Pathwayassociated24598718

References

Pubmed IDYearTitleCitations
152266752004High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1).69
216064172011SLCO2B1 and SLCO1B3 may determine time to progression for patients receiving androgen deprivation therapy for prostate cancer.59
212665232011Expression of SLCO transport genes in castration-resistant prostate cancer and impact of genetic variation in SLCO1B3 and SLCO2B1 on prostate cancer outcomes.50
201730832010Genetic variation in metabolizing enzyme and transporter genes: comprehensive assessment in 3 major East Asian subpopulations with comparison to Caucasians and Africans.44
121307472002Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis.43
121307472002Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis.43
124092832003Characterization and identification of steroid sulfate transporters of human placenta.34
169085972006Modification of OATP2B1-mediated transport by steroid hormones.33
199402672010Human skeletal muscle drug transporters determine local exposure and toxicity of statins.32
212784882011Expression and localization of the uptake transporters OATP2B1, OATP3A1 and OATP5A1 in non-malignant and malignant breast tissue.23

Citation

Dessen P

SLCO2B1 (solute carrier organic anion transporter family member 2B1)

Atlas Genet Cytogenet Oncol Haematol. 2011-07-01

Online version: http://atlasgeneticsoncology.org/gene/52268/slco2b1