SLFN14 (schlafen family member 14)

2014-11-01 Affiliation

Identity

HGNC

SLFN14

LOCATION

17q12

LOCUSID

342618

ALIAS

BDPLT20

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 342618
MIM: 614958
HGNC: 32689
Ensembl: ENSG00000236320

Variants:

dbSNP: 342618
ClinVar: 342618
TCGA: ENSG00000236320
COSMIC: SLFN14

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000236320	ENST00000415846	P0C7P3

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title
26280575	2015	SLFN14 mutations underlie thrombocytopenia with excessive bleeding and platelet secretion defects.
26769223	2016	SLFN14-related thrombocytopenia: identification within a large series of patients with inherited thrombocytopenia.
28734654	2017	Schlafen 14 (SLFN14) is a novel antiviral factor involved in the control of viral replication.
29678925	2018	Role of the novel endoribonuclease SLFN14 and its disease-causing mutations in ribosomal degradation.
30536060	2018	Identification of Two Mutations in PCDHGA4 and SLFN14 Genes in an Atrial Septal Defect Family.

Citation

Dessen P

SLFN14 (schlafen family member 14)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/73513/slfn14