SLIT1 (slit guidance ligand 1)

2008-12-01 Affiliation

Identity

HGNC

SLIT1

LOCATION

10q24.1

LOCUSID

6585

ALIAS

MEGF4,SLIL1,SLIT-1,SLIT3

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6585
MIM: 603742
HGNC: 11085
Ensembl: ENSG00000187122

Variants:

dbSNP: 6585
ClinVar: 6585
TCGA: ENSG00000187122
COSMIC: SLIT1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000187122	ENST00000266058	O75093
ENSG00000187122	ENST00000314867	Q5T0V4
ENSG00000187122	ENST00000371041	Q5T0V2
ENSG00000187122	ENST00000371070	Q5T0V0

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Axon guidance	KEGG	ko04360
Axon guidance	KEGG	hsa04360
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
Netrin-1 signaling	REACTOME	R-HSA-373752

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD
PA447288	Essential hypertension	Disease	ClinicalAnnotation	associated		PD
PA449552	etoposide	Chemical	ClinicalAnnotation	associated	PK	PD
PA449899	hydrochlorothiazide	Chemical	ClinicalAnnotation	associated		PD

References

Pubmed ID	Year	Title	Citations
16385451	2006	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	69
18829537	2008	SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium.	54
17062560	2006	A molecular mechanism for the heparan sulfate dependence of slit-robo signaling.	52
16162649	2005	Slit-mediated repulsion is a key regulator of motor axon pathfinding in the hindbrain.	38
16840550	2006	Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits.	25
29458143	2018	SUV39H2 promotes colorectal cancer proliferation and metastasis via tri-methylation of the SLIT1 promoter.	7
12141424	2002	Conserved modularity and potential for alternate splicing in mouse and human Slit genes.	2
31186493	2019	Clonal hematopoiesis by SLIT1-mutated hematopoietic stem cells due to a breakdown of the autocrine loop involving Slit1 in acquired aplastic anemia.	0

Citation

Dessen P

SLIT1 (slit guidance ligand 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50488/slit1