Identity
HGNC
LOCATION
18q21.1
LOCUSID
ALIAS
CRCS3,MADH7,MADH8
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4092
MIM: 602932
HGNC: 6773
Ensembl: ENSG00000101665
Variants:
dbSNP: 4092
ClinVar: 4092
TCGA: ENSG00000101665
COSMIC: SMAD7
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000101665 | ENST00000262158 | O15105 |
| ENSG00000101665 | ENST00000586093 | K7EKF0 |
| ENSG00000101665 | ENST00000589634 | O15105 |
| ENSG00000101665 | ENST00000591805 | O15105 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38177245 | 2024 | SMAD7 expression in CAR-T cells improves persistence and safety for solid tumors. | 2 |
| 38287200 | 2024 | Circular RNA circWNK1 inhibits the progression of gastric cancer via regulating the miR-21-3p/SMAD7 axis. | 3 |
| 38657333 | 2024 | UHRF1 inhibition mitigates vascular endothelial cell injury and ameliorates atherosclerosis in mice via regulating the SMAD7/YAP1 axis. | 0 |
| 39054719 | 2024 | Knockdown of YAP1 Reduces YTHDF3 to Stabilize SMAD7 and thus Inhibit Bladder Cancer Stem Cell Stemness. | 0 |
| 38177245 | 2024 | SMAD7 expression in CAR-T cells improves persistence and safety for solid tumors. | 2 |
| 38287200 | 2024 | Circular RNA circWNK1 inhibits the progression of gastric cancer via regulating the miR-21-3p/SMAD7 axis. | 3 |
| 38657333 | 2024 | UHRF1 inhibition mitigates vascular endothelial cell injury and ameliorates atherosclerosis in mice via regulating the SMAD7/YAP1 axis. | 0 |
| 39054719 | 2024 | Knockdown of YAP1 Reduces YTHDF3 to Stabilize SMAD7 and thus Inhibit Bladder Cancer Stem Cell Stemness. | 0 |
| 36377587 | 2023 | Are SMAD2/4/7 genetic variants associated with rheumatoid arthritis susceptibility and severity? | 0 |
| 36607878 | 2023 | Association of several loci of SMAD7 with colorectal cancer: A meta-analysis based on case-control studies. | 1 |
| 36690223 | 2023 | Genetic analysis and allele-specific expression of SMAD7 3'UTR variants in human colorectal cancer reveal a novel somatic variant exhibiting allelic imbalance. | 0 |
| 36845150 | 2023 | Hypermethylation of Smad7 in CD4(+) T cells is associated with the disease activity of rheumatoid arthritis. | 1 |
| 37376985 | 2023 | Overexpression of SMAD7 improves the function of EGFR-targeted human CAR-T cells against non-small-cell lung cancer. | 2 |
| 37382248 | 2023 | YES-associated protein-regulated Smad7 worsen epithelial barrier injury of chronic sinusitis with nasal polyps. | 0 |
| 37611637 | 2023 | TGF-β1 signaling and Smad7 control T-cell responses in health and immune-mediated disorders. | 2 |
Citation
Dessen P
SMAD7 (SMAD family member 7)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/41232/smad7
