SMARCD3 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3)

2003-05-01  

Identity

HGNC
LOCATION
7q36.1
LOCUSID
ALIAS
BAF60C,CRACD3,Rsc6p
FUSION GENES

Other Information

Locus ID:

NCBI: 6604
MIM: 601737
HGNC: 11108
Ensembl: ENSG00000082014

Variants:

dbSNP: 6604
ClinVar: 6604
TCGA: ENSG00000082014
COSMIC: SMARCD3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000082014ENST00000262188Q6STE5
ENSG00000082014ENST00000356800Q6STE5
ENSG00000082014ENST00000356800A0A090N8Z9
ENSG00000082014ENST00000392811Q6STE5
ENSG00000082014ENST00000392811A0A090N8Z9
ENSG00000082014ENST00000469154F8WBJ3
ENSG00000082014ENST00000485592H7C4E9
ENSG00000082014ENST00000491651C9JYI7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Mitochondrial biogenesisREACTOMER-HSA-1592230
Transcriptional activation of mitochondrial biogenesisREACTOMER-HSA-2151201
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
YAP1- and WWTR1 (TAZ)-stimulated gene expressionREACTOMER-HSA-2032785
Circadian ClockREACTOMER-HSA-400253
BMAL1:CLOCK,NPAS2 activates circadian gene expressionREACTOMER-HSA-1368108
RORA activates gene expressionREACTOMER-HSA-1368082
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Regulation of cholesterol biosynthesis by SREBP (SREBF)REACTOMER-HSA-1655829
Activation of gene expression by SREBF (SREBP)REACTOMER-HSA-2426168
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of white adipocyte differentiationREACTOMER-HSA-381340
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
RMTs methylate histone argininesREACTOMER-HSA-3214858

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
166874032006The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter.92
220680562012Signal-dependent incorporation of MyoD-BAF60c into Brg1-based SWI/SNF chromatin-remodelling complex.91
147018562004Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit.62
235637062013Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation.44
232195312013Phosphorylation and recruitment of BAF60c in chromatin remodeling for lipogenesis in response to insulin.30
237165992013SWI/SNF chromatin-remodeling factor Smarcd3/Baf60c controls epithelial-mesenchymal transition by inducing Wnt5a signaling.21
216947032011Directed differentiation of human embryonic stem cells to interrogate the cardiac gene regulatory network.17
188168252008Baf60c is a component of the neural progenitor-specific BAF complex in developing retina.15
228335602012Placenta to cartilage: direct conversion of human placenta to chondrocytes with transformation by defined factors.11
260711802015Gata4, Tbx5 and Baf60c induce differentiation of adipose tissue-derived mesenchymal stem cells into beating cardiomyocytes.3

Citation

Dessen P

SMARCD3 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42338/smarcd3