SMC4 (structural maintenance of chromosomes 4)

2007-11-01 Affiliation

Identity

HGNC

SMC4

LOCATION

3q25.33

LOCUSID

10051

ALIAS

CAP-C,CAPC,SMC-4,SMC4L1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10051
MIM: 605575
HGNC: 14013
Ensembl: ENSG00000113810

Variants:

dbSNP: 10051
ClinVar: 10051
TCGA: ENSG00000113810
COSMIC: SMC4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000113810	ENST00000344722	Q9NTJ3
ENSG00000113810	ENST00000357388	Q9NTJ3
ENSG00000113810	ENST00000462787	Q9NTJ3
ENSG00000113810	ENST00000465903	C9JWF0
ENSG00000113810	ENST00000467468	C9JVD8
ENSG00000113810	ENST00000469762	E9PD53
ENSG00000113810	ENST00000469858	F8WCB7
ENSG00000113810	ENST00000472991	C9J578
ENSG00000113810	ENST00000485645	C9IYK2
ENSG00000113810	ENST00000485867	C9J9E4
ENSG00000113810	ENST00000489573	C9JR83
ENSG00000113810	ENST00000490207	C9JJ64
ENSG00000113810	ENST00000497311	C9IYK2

Expression (GTEx)

100

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
M Phase	REACTOME	R-HSA-68886
Mitotic Prophase	REACTOME	R-HSA-68875
Condensation of Prophase Chromosomes	REACTOME	R-HSA-2299718
Mitotic Prometaphase	REACTOME	R-HSA-68877
Condensation of Prometaphase Chromosomes	REACTOME	R-HSA-2514853

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
25081869	2014	Low expression levels of microRNA-124-5p correlated with poor prognosis in colorectal cancer via targeting of SMC4.	36
17488335	2007	Condensin mutations and abnormal chromosomal structures in pyothorax-associated lymphoma.	19
22842912	2012	Overexpression of the structural maintenance of chromosome 4 protein is associated with tumor de-differentiation, advanced stage and vascular invasion of primary liver cancer.	17
20800603	2010	Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.	12
25422241	2014	Structural maintenance of chromosomes 4 is a predictor of survival and a novel therapeutic target in colorectal cancer.	9
26491021	2015	Structural Basis for Dimer Formation of Human Condensin Structural Maintenance of Chromosome Proteins and Its Implications for Single-stranded DNA Recognition.	4
31828143	2019	HIF-1-miR-219-SMC4 Regulatory Pathway Promoting Proliferation and Migration of HCC under Hypoxic Condition.	3
29043883	2018	Structural maintenance of chromosomes 4 is required for leukemia stem cell maintenance in MLL-AF9 induced acute myeloid leukemia.	1
29803706	2018	Condensin Smc4 promotes inflammatory innate immune response by epigenetically enhancing NEMO transcription.	1
31871499	2019	The Prognostic Value of the Expression of SMC4 mRNA in Breast Cancer.	0

Citation

Dessen P

SMC4 (structural maintenance of chromosomes 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-11-01

Online version: http://atlasgeneticsoncology.org/gene/49826/smc4