SMG1 (SMG1 nonsense mediated mRNA decay associated PI3K related kinase)

2006-10-01  

Identity

HGNC
LOCATION
16p12.3
LOCUSID
ALIAS
61E3.4,ATX,LIP
FUSION GENES

Other Information

Locus ID:

NCBI: 23049
MIM: 607032
HGNC: 30045
Ensembl: ENSG00000157106

Variants:

dbSNP: 23049
ClinVar: 23049
TCGA: ENSG00000157106
COSMIC: SMG1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000157106ENST00000330588A0A087WXM7
ENSG00000157106ENST00000446231Q96Q15
ENSG00000157106ENST00000532700E9PNP6
ENSG00000157106ENST00000561947I3L400
ENSG00000157106ENST00000563235H3BQN7
ENSG00000157106ENST00000563836H3BR09
ENSG00000157106ENST00000565224I3L0W2
ENSG00000157106ENST00000565324J3KRA9
ENSG00000157106ENST00000566328A0A087X1K8
ENSG00000157106ENST00000568038I3L144
ENSG00000157106ENST00000569122H3BPS6

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Gene ExpressionREACTOMER-HSA-74160
Nonsense-Mediated Decay (NMD)REACTOMER-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)REACTOMER-HSA-975957

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
164525072006Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay.245
194171042009SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay.95
151751542004The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells.84
208640322010CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability.73
222474952012Downregulation of SMG-1 in HPV-positive head and neck squamous cell carcinoma due to promoter hypermethylation correlates with improved survival.37
212451682011The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8.30
183328662008hSMG-1 and ATM sequentially and independently regulate the G1 checkpoint during oxidative stress.26
250023212014Structures of SMG1-UPFs complexes: SMG1 contributes to regulate UPF2-dependent activation of UPF1 in NMD.26
172297282007Distant N- and C-terminal domains are required for intrinsic kinase activity of SMG-1, a critical component of nonsense-mediated mRNA decay.23
183260482008A protective role for the human SMG-1 kinase against tumor necrosis factor-alpha-induced apoptosis.20

Citation

Dessen P

SMG1 (SMG1 nonsense mediated mRNA decay associated PI3K related kinase)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43495/smg1