SMG5 (SMG5 nonsense mediated mRNA decay factor)

2014-08-01  

Identity

HGNC
SMG5
LOCATION
1q22
LOCUSID
23381
ALIAS
EST1B,LPTS-RP1,LPTSRP1,SMG-5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23381
MIM: 610962
HGNC: 24644
Ensembl: ENSG00000198952

Variants:

dbSNP: 23381
ClinVar: 23381
TCGA: ENSG00000198952
COSMIC: SMG5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198952ENST00000361813Q9UPR3

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Gene ExpressionREACTOMER-HSA-74160
Nonsense-Mediated Decay (NMD)REACTOMER-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)REACTOMER-HSA-975957

References

Pubmed IDYearTitleCitations
146365772003Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7.131
252110802014The host nonsense-mediated mRNA decay pathway restricts Mammalian RNA virus replication.65
250131722014Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5-SMG7 and SMG6.39
168097642006Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation.32
293481392018Dissecting the functions of SMG5, SMG7, and PNRC2 in nonsense-mediated mRNA decay of human cells.8
274735912016MicroRNA 433 regulates nonsense-mediated mRNA decay by targeting SMG5 mRNA.1

Citation

Dessen P

SMG5 (SMG5 nonsense mediated mRNA decay factor)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54645/smg5