SMOC2 (SPARC related modular calcium binding 2)

2017-08-01  

Identity

HGNC
SMOC2
LOCATION
6q27
LOCUSID
64094
ALIAS
DTDP1,MST117,MSTP117,MSTP140,SMAP2,bA270C4A.1,bA37D8.1,dJ421D16.1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 64094
MIM: 607223
HGNC: 20323
Ensembl: ENSG00000112562

Variants:

dbSNP: 64094
ClinVar: 64094
TCGA: ENSG00000112562
COSMIC: SMOC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112562ENST00000354536Q9H3U7
ENSG00000112562ENST00000356284Q9H3U7
ENSG00000112562ENST00000392100H0Y3J4
ENSG00000112562ENST00000417208H0Y5I1
ENSG00000112562ENST00000535039A0A087WTM0

Expression (GTEx)

0
100
200
300
400
500
600
700
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
167749252006The novel SPARC family member SMOC-2 potentiates angiogenic growth factor activity.48
127419542003Characterization of SMOC-2, a modular extracellular calcium-binding protein.44
198903472010Genome-wide association study of generalized vitiligo in an isolated European founder population identifies SMOC2, in close proximity to IDDM8.25
198903472010Genome-wide association study of generalized vitiligo in an isolated European founder population identifies SMOC2, in close proximity to IDDM8.25
221526792011Homozygosity mapping and candidate prioritization identify mutations, missed by whole-exome sequencing, in SMOC2, causing major dental developmental defects.20
259158472016Induction of the intestinal stem cell signature gene SMOC-2 is required for L1-mediated colon cancer progression.18
209658052010SMOC2 gene variant and the risk of vitiligo in Jordanian Arabs.11
209658052010SMOC2 gene variant and the risk of vitiligo in Jordanian Arabs.11
172047272007Secreted modular calcium-binding protein 2 haplotypes are associated with pulmonary function.8

Citation

Dessen P

SMOC2 (SPARC related modular calcium binding 2)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/56922/smoc2