SNAP25 (synaptosome associated protein 25)

2008-12-01 Affiliation

Identity

HGNC

SNAP25

LOCATION

20p12.2

LOCUSID

6616

ALIAS

CMS18,RIC-4,RIC4,SEC9,SNAP,SNAP-25,SUP,bA416N4.2,dJ1068F16.2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6616
MIM: 600322
HGNC: 11132
Ensembl: ENSG00000132639

Variants:

dbSNP: 6616
ClinVar: 6616
TCGA: ENSG00000132639
COSMIC: SNAP25

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000132639	ENST00000254976	P60880
ENSG00000132639	ENST00000304886	P60880
ENSG00000132639	ENST00000430336	A0A0A0MSS0

Expression (GTEx)

500

1000

1500

2000

2500

3000

3500

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Synaptic vesicle cycle	KEGG	ko04721
Synaptic vesicle cycle	KEGG	hsa04721
Insulin secretion	KEGG	hsa04911
Neuronal System	REACTOME	R-HSA-112316
Transmission across Chemical Synapses	REACTOME	R-HSA-112315
Neurotransmitter Release Cycle	REACTOME	R-HSA-112310
Norepinephrine Neurotransmitter Release Cycle	REACTOME	R-HSA-181430
Serotonin Neurotransmitter Release Cycle	REACTOME	R-HSA-181429
Glutamate Neurotransmitter Release Cycle	REACTOME	R-HSA-210500
Dopamine Neurotransmitter Release Cycle	REACTOME	R-HSA-212676
Acetylcholine Neurotransmitter Release Cycle	REACTOME	R-HSA-264642
GABA synthesis, release, reuptake and degradation	REACTOME	R-HSA-888590
Disease	REACTOME	R-HSA-1643685
Infectious disease	REACTOME	R-HSA-5663205
Uptake and actions of bacterial toxins	REACTOME	R-HSA-5339562
Neurotoxicity of clostridium toxins	REACTOME	R-HSA-168799
Toxicity of botulinum toxin type A (BoNT/A)	REACTOME	R-HSA-5250968
Toxicity of botulinum toxin type E (BoNT/E)	REACTOME	R-HSA-5250992
Toxicity of botulinum toxin type C (BoNT/C)	REACTOME	R-HSA-5250971
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Metabolism	REACTOME	R-HSA-1430728
Integration of energy metabolism	REACTOME	R-HSA-163685
Regulation of insulin secretion	REACTOME	R-HSA-422356
Neutrophil degranulation	REACTOME	R-HSA-6798695

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19506906	2009	Candidate gene studies of ADHD: a meta-analytic review.	263
18821565	2008	Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations.	133
18519826	2008	Molecular genetics of successful smoking cessation: convergent genome-wide association study results.	130
15592454	2004	Substrate recognition strategy for botulinum neurotoxin serotype A.	114
18957941	2010	Genome-wide association scan for five major dimensions of personality.	80
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
15717291	2005	Support for association between ADHD and two candidate genes: NET1 and DRD1.	53
25418885	2014	SNAP-25 is a promising novel cerebrospinal fluid biomarker for synapse degeneration in Alzheimer's disease.	52
14709554	2004	Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphate.	49
19156168	2009	Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.	46

Citation

Dessen P

SNAP25 (synaptosome associated protein 25)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50575/snap25