SNCB (synuclein beta)

2010-04-01  

Identity

HGNC
SNCB
LOCATION
5q35.2
LOCUSID
6620
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6620
MIM: 602569
HGNC: 11140
Ensembl: ENSG00000074317

Variants:

dbSNP: 6620
ClinVar: 6620
TCGA: ENSG00000074317
COSMIC: SNCB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000074317ENST00000310112Q16143
ENSG00000074317ENST00000393693Q16143
ENSG00000074317ENST00000506696Q16143
ENSG00000074317ENST00000510387Q16143
ENSG00000074317ENST00000614675G4Y816

Expression (GTEx)

0
100
200
300
400
500
600
700
800
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
206932802010Membrane curvature induction and tubulation are common features of synucleins and apolipoproteins.118
118127822002Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly by beta- and gamma-synucleins.106
233195862013In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells.79
215933112011Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family.68
176815342007Residual structure, backbone dynamics, and interactions within the synuclein family.58
153651272004Beta-synuclein gene alterations in dementia with Lewy bodies.42
184369572008Molecular determinants of the aggregation behavior of alpha- and beta-synuclein.34
169597932006Beta-synuclein modulates alpha-synuclein neurotoxicity by reducing alpha-synuclein protein expression.27
165978212006Secondary structure and dynamics of micelle bound beta- and gamma-synuclein.25
176535582007Neuronal and glial accumulation of alpha- and beta-synucleins in human lipidoses.25

Citation

Dessen P

SNCB (synuclein beta)

Atlas Genet Cytogenet Oncol Haematol. 2010-04-01

Online version: http://atlasgeneticsoncology.org/gene/51427/sncb