SNX10 (sorting nexin 10)

2014-08-01  

Identity

HGNC
SNX10
LOCATION
7p15.2
LOCUSID
29887
ALIAS
OPTB8
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 29887
MIM: 614780
HGNC: 14974
Ensembl: ENSG00000086300

Variants:

dbSNP: 29887
ClinVar: 29887
TCGA: ENSG00000086300
COSMIC: SNX10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000086300ENST00000338523Q9Y5X0
ENSG00000086300ENST00000338523A0A024RA70
ENSG00000086300ENST00000396376Q9Y5X0
ENSG00000086300ENST00000396376A0A024RA70
ENSG00000086300ENST00000409367G5E9H5
ENSG00000086300ENST00000409838Q9Y5X0
ENSG00000086300ENST00000412416C9JUQ6
ENSG00000086300ENST00000416246C9JQ16
ENSG00000086300ENST00000446848Q9Y5X0
ENSG00000086300ENST00000446848A0A024RA70
ENSG00000086300ENST00000619420A0A087WUJ3

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
218448912012A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo.23
170122262006Sorting nexin 10 induces giant vacuoles in mammalian cells.21
224993392012An SNX10 mutation causes malignant osteopetrosis of infancy.20
232809652013SNX10 mutations define a subgroup of human autosomal recessive osteopetrosis with variable clinical severity.14
221741882012SNX10 is required for osteoclast formation and resorption activity.10
293556592018Sorting nexin 10 acts as a tumor suppressor in tumorigenesis and progression of colorectal cancer through regulating chaperone mediated autophagy degradation of p21Cip1/WAF1.8
285928082017SNX10 gene mutation leading to osteopetrosis with dysfunctional osteoclasts.7
236159012013Structure of sorting nexin 11 (SNX11) reveals a novel extended phox homology (PX) domain critical for inhibition of SNX10-induced vacuolation.6
258119862015Osteopetrorickets due to Snx10 deficiency in mice results from both failed osteoclast activity and loss of gastric acid-dependent calcium absorption.6
298671142018Sorting nexin 10 controls mTOR activation through regulating amino-acid metabolism in colorectal cancer.5

Citation

Dessen P

SNX10 (sorting nexin 10)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54651/snx10