SNX17 (sorting nexin 17)

2014-11-01  

Identity

HGNC
SNX17
LOCATION
2p23.3
LOCUSID
9784
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9784
MIM: 605963
HGNC: 14979
Ensembl: ENSG00000115234

Variants:

dbSNP: 9784
ClinVar: 9784
TCGA: ENSG00000115234
COSMIC: SNX17

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115234ENST00000233575Q15036
ENSG00000115234ENST00000427123F8WAZ0
ENSG00000115234ENST00000440760F8WFA0
ENSG00000115234ENST00000453453F8WEG6
ENSG00000115234ENST00000537606Q15036

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
224927272012SNX17 protects integrins from degradation by sorting between lysosomal and recycling pathways.71
182765902008Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes.57
160522102005Sorting nexin 17 facilitates LRP recycling in the early endosome.53
262022512015A Novel PDZ Domain Interaction Mediates the Binding between Human Papillomavirus 16 L2 and Sorting Nexin 27 and Modulates Virion Trafficking.27
231152882013SNX17 facilitates infection with diverse papillomavirus types.26
157694722005Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking.21
258254392015SNX17 affects T cell activation by regulating TCR and integrin recycling.17
167127982006Sorting nexin 17, a non-self-assembling and a PtdIns(3)P high class affinity protein, interacts with the cerebral cavernous malformation related protein KRIT1.13
247053692014Sorting nexin 17 regulates ApoER2 recycling and reelin signaling.12
250596592014Structural determinants for binding of sorting nexin 17 (SNX17) to the cytoplasmic adaptor protein Krev interaction trapped 1 (KRIT1).8

Citation

Dessen P

SNX17 (sorting nexin 17)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74051/snx17