SNX4 (sorting nexin 4)

2014-08-01  

Identity

HGNC
SNX4
LOCATION
3q21.2
LOCUSID
8723
ALIAS
ATG24B
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8723
MIM: 605931
HGNC: 11175
Ensembl: ENSG00000114520

Variants:

dbSNP: 8723
ClinVar: 8723
TCGA: ENSG00000114520
COSMIC: SNX4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114520ENST00000251775O95219
ENSG00000114520ENST00000465505F8W9T3
ENSG00000114520ENST00000471751F8WDD4

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
179940112007SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment.102
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
219730562012SNX-BAR-mediated endosome tubulation is co-ordinated with endosome maturation.54
126687302003Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking.24
195297632009SNX4 in complex with clathrin and dynein: implications for endosome movement.17
173198032007Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins.16
281093172017Sorting nexin-4 regulates β-amyloid production by modulating β-site-activating cleavage enzyme-1.7
246909212014α-Taxilin interacts with sorting nexin 4 and participates in the recycling pathway of transferrin receptor.2

Citation

Dessen P

SNX4 (sorting nexin 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54653/snx4