SOAT1 (sterol O-acyltransferase 1)

2007-02-01  

Identity

HGNC
LOCATION
1q25.2
LOCUSID
ALIAS
ACACT,ACAT,ACAT-1,ACAT1,SOAT,STAT
FUSION GENES

Other Information

Locus ID:

NCBI: 6646
MIM: 102642
HGNC: 11177
Ensembl: ENSG00000057252

Variants:

dbSNP: 6646
ClinVar: 6646
TCGA: ENSG00000057252
COSMIC: SOAT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000057252ENST00000367619P35610
ENSG00000057252ENST00000426956B1APM4
ENSG00000057252ENST00000539888P35610
ENSG00000057252ENST00000540564P35610

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Steroid biosynthesisKEGGko00100
Steroid biosynthesisKEGGhsa00100
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Lipoprotein metabolismREACTOMER-HSA-174824
LDL-mediated lipid transportREACTOMER-HSA-171052

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
272815602016Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis.45
198518602010High ACAT1 expression in estrogen receptor negative basal-like breast cancer cells is associated with LDL-induced proliferation.42
263058862015Mitotane Inhibits Sterol-O-Acyl Transferase 1 Triggering Lipid-Mediated Endoplasmic Reticulum Stress and Apoptosis in Adrenocortical Carcinoma Cells.41
160139132005A cluster of cholesterol-related genes confers susceptibility for Alzheimer's disease.38
161549942005The active site His-460 of human acyl-coenzyme A:cholesterol acyltransferase 1 resides in a hitherto undisclosed transmembrane domain.30
153086312004Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells.28
195025902009Signaling through cholesterol esterification: a new pathway for the cholecystokinin 2 receptor involved in cell growth and invasion.24
159923592005Investigating the allosterism of acyl-CoA:cholesterol acyltransferase (ACAT) by using various sterols: in vitro and intact cell studies.23
253397592014Inhibiting ACAT1/SOAT1 in microglia stimulates autophagy-mediated lysosomal proteolysis and increases Aβ1-42 clearance.23

Citation

Dessen P

SOAT1 (sterol O-acyltransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43926/soat1