SOCS4 (suppressor of cytokine signaling 4)

2010-08-01  

Identity

HGNC
LOCATION
14q22.3
LOCUSID
ALIAS
SOCS7
FUSION GENES

Other Information

Locus ID:

NCBI: 122809
MIM: 616337
HGNC: 19392
Ensembl: ENSG00000180008

Variants:

dbSNP: 122809
ClinVar: 122809
TCGA: ENSG00000180008
COSMIC: SOCS4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000180008ENST00000339298Q8WXH5
ENSG00000180008ENST00000339298Q5H9R6
ENSG00000180008ENST00000395472Q8WXH5
ENSG00000180008ENST00000395472Q5H9R6
ENSG00000180008ENST00000555846Q8WXH5
ENSG00000180008ENST00000555846Q5H9R6

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Jak-STAT signaling pathwayKEGGko04630
Insulin signaling pathwayKEGGko04910
Type II diabetes mellitusKEGGko04930
Jak-STAT signaling pathwayKEGGhsa04630
Insulin signaling pathwayKEGGhsa04910
Type II diabetes mellitusKEGGhsa04930
ECS complexKEGGhsa_M00388
ECS complexKEGGM00388
Prolactin signaling pathwayKEGGhsa04917
Prolactin signaling pathwayKEGGko04917
JAK-STAT signalingKEGGhsa_M00684
JAK-STAT signalingKEGGM00684

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
155906942005Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling.50
179979742007Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation.48
204337502010Higher expression levels of SOCS 1,3,4,7 are associated with earlier tumour stage and better clinical outcome in human breast cancer.34
204868572010MicroRNA-98 and let-7 regulate expression of suppressor of cytokine signaling 4 in biliary epithelial cells in response to Cryptosporidium parvum infection.29
194235402009Common variation in genes related to innate immunity and risk of adult glioma.19
221274252012Suppressor of cytokine signaling 4 detected as a novel gastric cancer suppressor gene using double combination array analysis.16
204069642010Risk of meningioma and common variation in genes related to innate immunity.12
252863862015Expression of suppressor of cytokine signaling genes in human elderly and Alzheimer's disease brains and human microglia.12
224233602012The N-terminal domains of SOCS proteins: a conserved region in the disordered N-termini of SOCS4 and 5.9
264374442015Interleukin-23 Facilitates Thyroid Cancer Cell Migration and Invasion by Inhibiting SOCS4 Expression via MicroRNA-25.8

Citation

Dessen P

SOCS4 (suppressor of cytokine signaling 4)

Atlas Genet Cytogenet Oncol Haematol. 2010-08-01

Online version: http://atlasgeneticsoncology.org/gene/51617/socs4