SOD2 (superoxide dismutase 2)

2003-08-01 Affiliation

HGNC

SOD2

LOCATION

6q25.3

LOCUSID

6648

ALIAS

GClnc1,IPO-B,IPOB,MNSOD,MVCD6,Mn-SOD

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

dbSNP: 6648
ClinVar: 6648
TCGA: ENSG00000285441
COSMIC: SOD2

Pathway	Source	External ID
Huntington's disease	KEGG	ko05016
Huntington's disease	KEGG	hsa05016
Peroxisome	KEGG	ko04146
Peroxisome	KEGG	hsa04146
FoxO signaling pathway	KEGG	hsa04068
Disease	REACTOME	R-HSA-1643685
Cellular responses to stress	REACTOME	R-HSA-2262752
Detoxification of Reactive Oxygen Species	REACTOME	R-HSA-3299685
Longevity regulating pathway	KEGG	hsa04211
Longevity regulating pathway - multiple species	KEGG	ko04213
Longevity regulating pathway - multiple species	KEGG	hsa04213
Neurodegenerative Diseases	REACTOME	R-HSA-8863678
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	REACTOME	R-HSA-8862803

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA443560	Breast Neoplasms	Disease	ClinicalAnnotation	associated	PD	25495407
PA444065	Epilepsy	Disease	ClinicalAnnotation	associated	PD
PA444460	Heroin Dependence	Disease	ClinicalAnnotation	associated	PD	29459008
PA446155	Precursor Cell Lymphoblastic Leukemia-Lymphoma	Disease	ClinicalAnnotation	associated	PD	27019981
PA448492	asparaginase	Chemical	ClinicalAnnotation	associated	PD	27019981
PA449165	cyclophosphamide	Chemical	ClinicalAnnotation	associated	PD
PA450428	methotrexate	Chemical	ClinicalAnnotation, MultilinkAnnotation	associated	PD	25330300
PA450761	paclitaxel	Chemical	ClinicalAnnotation	associated	PD	25495407
PA451846	valproic acid	Chemical	ClinicalAnnotation	associated	PD
PA452619	heroin	Chemical	ClinicalAnnotation	associated	PD	29459008

Pubmed ID	Year	Title	Citations
12239572	2002	Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress.	484
18583979	2008	Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.	395
17293864	2007	A common coding variant in CASP8 is associated with breast cancer risk.	218
21566644	2011	Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS.	192
15166009	2004	Vascular protection: superoxide dismutase isoforms in the vessel wall.	132
20089851	2010	Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure.	110
15701646	2005	Mitochondrial H2O2 regulates the angiogenic phenotype via PTEN oxidation.	92
16166634	2005	Protein kinase D mediates mitochondrion-to-nucleus signaling and detoxification from mitochondrial reactive oxygen species.	90
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
17018785	2006	Commonly studied single-nucleotide polymorphisms and breast cancer: results from the Breast Cancer Association Consortium.	83

Dessen P

SOD2 (superoxide dismutase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01