SORCS2 (sortilin related VPS10 domain containing receptor 2)

2014-11-01  

Identity

HGNC
LOCATION
4p16.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 57537
MIM: 606284
HGNC: 16698
Ensembl: ENSG00000184985

Variants:

dbSNP: 57537
ClinVar: 57537
TCGA: ENSG00000184985
COSMIC: SORCS2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184985ENST00000329016B5MED8
ENSG00000184985ENST00000505529H0Y9I2
ENSG00000184985ENST00000507866Q96PQ0

Expression (GTEx)

0
5
10
15
20
25
30
35

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10251atazanavirChemicalClinicalAnnotationassociatedPK31562781
PA447230HIV InfectionsDiseaseClinicalAnnotationassociatedPK31562781

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
200806502010Inherited genetic variant predisposes to aggressive but not indolent prostate cancer.46
193080212009Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort.29
193285582009Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population.11
201983152010Association of genetic variants with hemorrhagic stroke in Japanese individuals.11
264200262015Sortilin-related receptor CNS expressed 2 (SorCS2) is localized to Bunina bodies in amyotrophic lateral sclerosis.4
198512962010Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.3
308408982019SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology.3
288271482017Hidden Twins: SorCS Neuroreceptors Form Stable Dimers.2
302529352018Risk Locus Identification Ties Alcohol Withdrawal Symptoms to SORCS2.2

Citation

Dessen P

SORCS2 (sortilin related VPS10 domain containing receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74072/sorcs2