SORCS3 (sortilin related VPS10 domain containing receptor 3)

2014-11-01  

Identity

HGNC
LOCATION
10q25.1
LOCUSID
ALIAS
SORCS
FUSION GENES

Other Information

Locus ID:

NCBI: 22986
MIM: 606285
HGNC: 16699
Ensembl: ENSG00000156395

Variants:

dbSNP: 22986
ClinVar: 22986
TCGA: ENSG00000156395
COSMIC: SORCS3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156395ENST00000369699Q9UPU3
ENSG00000156395ENST00000369701Q9UPU3
ENSG00000156395ENST00000393176Q5CAJ2

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
157104082005SorCS3 does not require propeptide cleavage to bind nerve growth factor.11
288271482017Hidden Twins: SorCS Neuroreceptors Form Stable Dimers.2
263628882016Genetic analysis of the isolated Faroe Islands reveals SORCS3 as a potential multiple sclerosis risk gene.1
305865382018The SORCS3 gene is mutated in brothers with infantile spasms and intellectual disability.1

Citation

Dessen P

SORCS3 (sortilin related VPS10 domain containing receptor 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74073/sorcs3