SOX7 (SRY-box transcription factor 7)

2003-10-01  

Identity

HGNC
LOCATION
8p23.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 83595
MIM: 612202
HGNC: 18196
Ensembl: ENSG00000171056

Variants:

dbSNP: 83595
ClinVar: 83595
TCGA: ENSG00000171056
COSMIC: SOX7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171056ENST00000304501Q9BT81

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Deactivation of the beta-catenin transactivating complexREACTOMER-HSA-3769402

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
186822402008Establishment of endoderm progenitors by SOX transcription factor expression in human embryonic stem cells.71
116919152001SOX7 transcription factor: sequence, chromosomal localisation, expression, transactivation and interference with Wnt signalling.57
188199302008Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells.37
232958592012Down-regulation of Sox7 is associated with aberrant activation of Wnt/b-catenin signaling in endometrial cancer.33
271505622016The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages.31
191089502009SOX7, down-regulated in colorectal cancer, induces apoptosis and inhibits proliferation of colorectal cancer cells.27
245584292014Mir-184 post-transcriptionally regulates SOX7 expression and promotes cell proliferation in human hepatocellular carcinoma.23
235572162013SOX7 is down-regulated in lung cancer.22
254074882015MiR-492 contributes to cell proliferation and cell cycle of human breast cancer cells by suppressing SOX7 expression.22
227779182012Decreased expression of SOX7 is correlated with poor prognosis in lung adenocarcinoma patients.19

Citation

Dessen P

SOX7 (SRY-box transcription factor 7)

Atlas Genet Cytogenet Oncol Haematol. 2003-10-01

Online version: http://atlasgeneticsoncology.org/gene/42359/sox7